Orthotopic liver transplantation in hemophilia B: a case report

Z. Kadry, P. de Moerloose, E. Giostra, P. Morel, O. Huber, E. Meili, H. E. Blum, G. Mentha

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11 Scopus citations


Liver transplantation is a treatment modality that is being used with increasing frequency in cases of liver-based metabolic defects. This is a case report of a patient with hemophilia B who was treated since childhood with factor IX replacement for recurrent hemarthroses. Subsequent hepatitis B (HBV) and C (HCV) infection had resulted in the development of chronic active hepatitis, ultimately leading to cirrhosis. Orthotopic liver transplantation performed for endstage liver disease resulted in a rise in factor IX levels from 2% to 83% of normal values within 24 h post-operatively, and levels remained above 90% of normal values after postoperative day 3 without factor IX replacement. To our knowledge, only two cases of hemophilia B treated by orthotopic liver transplantation have been reported. This procedure has, however, only been implemented in cases of terminal liver insufficiency in hemophiliacs.

Original languageEnglish (US)
Pages (from-to)485-487
Number of pages3
JournalTransplant International
Issue number6
StatePublished - Nov 1995

All Science Journal Classification (ASJC) codes

  • Transplantation


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