Otx2, Gbx2 and Fgf8 interact to position and maintain a mid-hindbrain organizer

Alexandra L. Joyner, Aimin Liu, Sandrine Millet

Research output: Contribution to journalReview articlepeer-review

235 Scopus citations

Abstract

A decade ago, chick-quail transplantation studies demonstrated that the junction between the midbrain and hindbrain has the properties of an organizing center capable of patterning the midbrain and cerebellum. Many of the genes that function to pattern these tissues have been identified and extensively studied. Recent experiments have shown that Otx2, Gbx2 and Fgf8 genes play a major role in the positioning and functioning of this organizing center.

Original languageEnglish (US)
Pages (from-to)736-741
Number of pages6
JournalCurrent Opinion in Cell Biology
Volume12
Issue number6
DOIs
StatePublished - Jan 1 2000

All Science Journal Classification (ASJC) codes

  • Cell Biology

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