Outcome of heart transplantation in pediatric cancer survivors

Nishant Shah, Sanjeev Aggarwal, Thomas L'Ecuyer

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The aim of this study is to evaluate the outcome of heart transplantation in children surviving malignancies. Pediatric heart transplant recipients were identified using the UNOS database. Follow-up data including survival and rate of malignancy were analyzed. A total of 7169 children received heart transplants between 1987 and 2011. Of these, 107 (1.5%) survived previous malignancy treatment (group I) and 7062 (98.5%) did not have prior malignancy (group II). Survival after transplant was 92.5%, 90.6%, 80.3%, and 65% at three months, one, five, and 10 yr in group I, similar to the rate in group II (90.1%, 84.4%, 73.8%, and 57.7%). Survival after transplantation was similar between group I and children who underwent OHT secondary to cardiomyopathy in group II. The rate of post-OHT malignancy in group I was higher than that in group II (14/107(13%) vs. 386/7062 (5.4%), p = 0.001). Children who developed malignancy in group I had similar survival as children who developed malignancy in group II. Post-transplant survival is similar in children with and without pretransplant malignancy in spite of higher rate of malignancy in children with pretransplant malignancy. OHT appears to be a reasonable treatment option in children who develop end-stage heart disease after malignancy treatment.

Original languageEnglish (US)
Pages (from-to)423-428
Number of pages6
JournalPediatric Transplantation
Volume17
Issue number5
DOIs
StatePublished - Aug 2013

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Heart Transplantation
Survivors
Pediatrics
Neoplasms
Transplants
Survival
Cardiomyopathies
Heart Diseases
Therapeutics
Survival Rate
Transplantation
Databases

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Transplantation

Cite this

Shah, Nishant ; Aggarwal, Sanjeev ; L'Ecuyer, Thomas. / Outcome of heart transplantation in pediatric cancer survivors. In: Pediatric Transplantation. 2013 ; Vol. 17, No. 5. pp. 423-428.
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Outcome of heart transplantation in pediatric cancer survivors. / Shah, Nishant; Aggarwal, Sanjeev; L'Ecuyer, Thomas.

In: Pediatric Transplantation, Vol. 17, No. 5, 08.2013, p. 423-428.

Research output: Contribution to journalArticle

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