Overexpression of mRNA-binding protein CRD-BP in malignant melanomas

I. Elcheva; R. S. Tarapore; N. Bhatia; V. S. Spiegelman

doi:10.1038/onc.2008.141

Overexpression of mRNA-binding protein CRD-BP in malignant melanomas

I. Elcheva, R. S. Tarapore, N. Bhatia, V. S. Spiegelman

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

Wnt/β-catenin signaling pathway plays an important role in embryogenesis, stem cell maintenance, tumorigenesis and aging. Here, we show that RNA-binding protein, coding region determinant-binding protein (CRD-BP) (a transcriptional target of Wnt signaling pathway), is highly expressed in primary human malignant melanomas and melanoma cell lines with activated Wnt/β-catenin signaling pathway. Upregulation of CRD-BP is associated with an elevated level of β-TrCP1 ubiquitin ligase receptor and activation of nuclear transcriptional factors-kappa B (NF-κB) signaling. Knockdown of CRD-BP inhibits NF-κB activity, induces apoptosis, and suppresses proliferation and tumorigenic properties of melanoma cells.

Original language	English (US)
Pages (from-to)	5069-5074
Number of pages	6
Journal	Oncogene
Volume	27
Issue number	37
DOIs	https://doi.org/10.1038/onc.2008.141
State	Published - Aug 28 2008

All Science Journal Classification (ASJC) codes

Molecular Biology
Genetics
Cancer Research

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@article{81171a3fbbec4941802cb647bd275570,

title = "Overexpression of mRNA-binding protein CRD-BP in malignant melanomas",

abstract = "Wnt/β-catenin signaling pathway plays an important role in embryogenesis, stem cell maintenance, tumorigenesis and aging. Here, we show that RNA-binding protein, coding region determinant-binding protein (CRD-BP) (a transcriptional target of Wnt signaling pathway), is highly expressed in primary human malignant melanomas and melanoma cell lines with activated Wnt/β-catenin signaling pathway. Upregulation of CRD-BP is associated with an elevated level of β-TrCP1 ubiquitin ligase receptor and activation of nuclear transcriptional factors-kappa B (NF-κB) signaling. Knockdown of CRD-BP inhibits NF-κB activity, induces apoptosis, and suppresses proliferation and tumorigenic properties of melanoma cells.",

author = "I. Elcheva and Tarapore, {R. S.} and N. Bhatia and Spiegelman, {V. S.}",

note = "Funding Information: We thank Drs N Maddodi, S Devi, J Ross, P Robbins, K Kinzler and B Vogelstein for their generous gifts of reagents, S Reagan-Shaw for statistical analysis, Drs V Setaluri and S Fuchs for critical reading of the paper, and Dr K Spiegelman and Ms I Larsen for help with the paper preparation. This study was supported by NCI Grant CA121851 (to VSS).",

year = "2008",

month = aug,

day = "28",

doi = "10.1038/onc.2008.141",

language = "English (US)",

volume = "27",

pages = "5069--5074",

journal = "Oncogene",

issn = "0950-9232",

publisher = "Nature Publishing Group",

number = "37",

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T1 - Overexpression of mRNA-binding protein CRD-BP in malignant melanomas

AU - Elcheva, I.

AU - Tarapore, R. S.

AU - Bhatia, N.

AU - Spiegelman, V. S.

N1 - Funding Information: We thank Drs N Maddodi, S Devi, J Ross, P Robbins, K Kinzler and B Vogelstein for their generous gifts of reagents, S Reagan-Shaw for statistical analysis, Drs V Setaluri and S Fuchs for critical reading of the paper, and Dr K Spiegelman and Ms I Larsen for help with the paper preparation. This study was supported by NCI Grant CA121851 (to VSS).

PY - 2008/8/28

Y1 - 2008/8/28

N2 - Wnt/β-catenin signaling pathway plays an important role in embryogenesis, stem cell maintenance, tumorigenesis and aging. Here, we show that RNA-binding protein, coding region determinant-binding protein (CRD-BP) (a transcriptional target of Wnt signaling pathway), is highly expressed in primary human malignant melanomas and melanoma cell lines with activated Wnt/β-catenin signaling pathway. Upregulation of CRD-BP is associated with an elevated level of β-TrCP1 ubiquitin ligase receptor and activation of nuclear transcriptional factors-kappa B (NF-κB) signaling. Knockdown of CRD-BP inhibits NF-κB activity, induces apoptosis, and suppresses proliferation and tumorigenic properties of melanoma cells.

AB - Wnt/β-catenin signaling pathway plays an important role in embryogenesis, stem cell maintenance, tumorigenesis and aging. Here, we show that RNA-binding protein, coding region determinant-binding protein (CRD-BP) (a transcriptional target of Wnt signaling pathway), is highly expressed in primary human malignant melanomas and melanoma cell lines with activated Wnt/β-catenin signaling pathway. Upregulation of CRD-BP is associated with an elevated level of β-TrCP1 ubiquitin ligase receptor and activation of nuclear transcriptional factors-kappa B (NF-κB) signaling. Knockdown of CRD-BP inhibits NF-κB activity, induces apoptosis, and suppresses proliferation and tumorigenic properties of melanoma cells.

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