Overexpression of mRNA-binding protein CRD-BP in malignant melanomas

I. Elcheva, R. S. Tarapore, N. Bhatia, V. S. Spiegelman

Research output: Contribution to journalArticlepeer-review

38 Scopus citations

Abstract

Wnt/β-catenin signaling pathway plays an important role in embryogenesis, stem cell maintenance, tumorigenesis and aging. Here, we show that RNA-binding protein, coding region determinant-binding protein (CRD-BP) (a transcriptional target of Wnt signaling pathway), is highly expressed in primary human malignant melanomas and melanoma cell lines with activated Wnt/β-catenin signaling pathway. Upregulation of CRD-BP is associated with an elevated level of β-TrCP1 ubiquitin ligase receptor and activation of nuclear transcriptional factors-kappa B (NF-κB) signaling. Knockdown of CRD-BP inhibits NF-κB activity, induces apoptosis, and suppresses proliferation and tumorigenic properties of melanoma cells.

Original languageEnglish (US)
Pages (from-to)5069-5074
Number of pages6
JournalOncogene
Volume27
Issue number37
DOIs
StatePublished - Aug 28 2008

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics
  • Cancer Research

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