Abstract
Wnt/β-catenin signaling pathway plays an important role in embryogenesis, stem cell maintenance, tumorigenesis and aging. Here, we show that RNA-binding protein, coding region determinant-binding protein (CRD-BP) (a transcriptional target of Wnt signaling pathway), is highly expressed in primary human malignant melanomas and melanoma cell lines with activated Wnt/β-catenin signaling pathway. Upregulation of CRD-BP is associated with an elevated level of β-TrCP1 ubiquitin ligase receptor and activation of nuclear transcriptional factors-kappa B (NF-κB) signaling. Knockdown of CRD-BP inhibits NF-κB activity, induces apoptosis, and suppresses proliferation and tumorigenic properties of melanoma cells.
Original language | English (US) |
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Pages (from-to) | 5069-5074 |
Number of pages | 6 |
Journal | Oncogene |
Volume | 27 |
Issue number | 37 |
DOIs | |
State | Published - Aug 28 2008 |
All Science Journal Classification (ASJC) codes
- Molecular Biology
- Genetics
- Cancer Research