Overshoot of oxygen pressure in post-hypoxic brain tissue: a re-evaluation

Steven J. Schiff; George G. Somjen

doi:10.1016/0006-8993(85)91200-4

Overshoot of oxygen pressure in post-hypoxic brain tissue: a re-evaluation

Steven J. Schiff, George G. Somjen

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Tissue oxygen pressure (p_tO₂) was measured with noble metal microelectrodes in hippocampal slices in vitro. During hypoxia, the p_tO₂ at 100 μm depth fell rapidly to less than 20 mm Hg. During reoxygenation, large transient p_tO₂ increases above normoxic values were observed. These data demonstrate that p_tO₂ 'overshoots' occur independently of in situ posthypoxic hyperemia and may reflect pathologic chemical reactions in brain tissue during reoxygenation.

Original language	English (US)
Pages (from-to)	150-153
Number of pages	4
Journal	Brain research
Volume	344
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(85)91200-4
State	Published - Sep 30 1985

All Science Journal Classification (ASJC) codes

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

Access to Document

10.1016/0006-8993(85)91200-4

Cite this

@article{34345263409249a2b8e2f7379375f7e2,

title = "Overshoot of oxygen pressure in post-hypoxic brain tissue: a re-evaluation",

abstract = "Tissue oxygen pressure (ptO2) was measured with noble metal microelectrodes in hippocampal slices in vitro. During hypoxia, the ptO2 at 100 μm depth fell rapidly to less than 20 mm Hg. During reoxygenation, large transient ptO2 increases above normoxic values were observed. These data demonstrate that ptO2 'overshoots' occur independently of in situ posthypoxic hyperemia and may reflect pathologic chemical reactions in brain tissue during reoxygenation.",

author = "Schiff, {Steven J.} and Somjen, {George G.}",

note = "Funding Information: The advice of P.G. Aitken, A.L. Sylvia and I. Fri-dovich has been very much appreciated. We also thank Dr. Sylvia for the use of the blood gas analyzer. Supported by the Research Foundation of the American Association of Neurological Surgery and USPHS Grant NS 18670. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.",

year = "1985",

month = sep,

day = "30",

doi = "10.1016/0006-8993(85)91200-4",

language = "English (US)",

volume = "344",

pages = "150--153",

journal = "Brain Research",

issn = "0006-8993",

publisher = "Elsevier",

number = "1",

}

TY - JOUR

T1 - Overshoot of oxygen pressure in post-hypoxic brain tissue

T2 - a re-evaluation

AU - Schiff, Steven J.

AU - Somjen, George G.

N1 - Funding Information: The advice of P.G. Aitken, A.L. Sylvia and I. Fri-dovich has been very much appreciated. We also thank Dr. Sylvia for the use of the blood gas analyzer. Supported by the Research Foundation of the American Association of Neurological Surgery and USPHS Grant NS 18670. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.

PY - 1985/9/30

Y1 - 1985/9/30

N2 - Tissue oxygen pressure (ptO2) was measured with noble metal microelectrodes in hippocampal slices in vitro. During hypoxia, the ptO2 at 100 μm depth fell rapidly to less than 20 mm Hg. During reoxygenation, large transient ptO2 increases above normoxic values were observed. These data demonstrate that ptO2 'overshoots' occur independently of in situ posthypoxic hyperemia and may reflect pathologic chemical reactions in brain tissue during reoxygenation.

AB - Tissue oxygen pressure (ptO2) was measured with noble metal microelectrodes in hippocampal slices in vitro. During hypoxia, the ptO2 at 100 μm depth fell rapidly to less than 20 mm Hg. During reoxygenation, large transient ptO2 increases above normoxic values were observed. These data demonstrate that ptO2 'overshoots' occur independently of in situ posthypoxic hyperemia and may reflect pathologic chemical reactions in brain tissue during reoxygenation.

UR - http://www.scopus.com/inward/record.url?scp=0022007367&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022007367&partnerID=8YFLogxK

U2 - 10.1016/0006-8993(85)91200-4

DO - 10.1016/0006-8993(85)91200-4

M3 - Article

C2 - 4041862

AN - SCOPUS:0022007367

VL - 344

SP - 150

EP - 153

JO - Brain Research

JF - Brain Research

SN - 0006-8993

IS - 1

ER -

Overshoot of oxygen pressure in post-hypoxic brain tissue: a re-evaluation

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this