Abstract
Tissue oxygen pressure (ptO2) was measured with noble metal microelectrodes in hippocampal slices in vitro. During hypoxia, the ptO2 at 100 μm depth fell rapidly to less than 20 mm Hg. During reoxygenation, large transient ptO2 increases above normoxic values were observed. These data demonstrate that ptO2 'overshoots' occur independently of in situ posthypoxic hyperemia and may reflect pathologic chemical reactions in brain tissue during reoxygenation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 150-153 |
| Number of pages | 4 |
| Journal | Brain research |
| Volume | 344 |
| Issue number | 1 |
| DOIs | |
| State | Published - Sep 30 1985 |
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All Science Journal Classification (ASJC) codes
- Neuroscience(all)
- Molecular Biology
- Clinical Neurology
- Developmental Biology
Cite this
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Overshoot of oxygen pressure in post-hypoxic brain tissue : a re-evaluation. / Schiff, Steven; Somjen, George G.
In: Brain research, Vol. 344, No. 1, 30.09.1985, p. 150-153.Research output: Contribution to journal › Article
TY - JOUR
T1 - Overshoot of oxygen pressure in post-hypoxic brain tissue
T2 - a re-evaluation
AU - Schiff, Steven
AU - Somjen, George G.
PY - 1985/9/30
Y1 - 1985/9/30
N2 - Tissue oxygen pressure (ptO2) was measured with noble metal microelectrodes in hippocampal slices in vitro. During hypoxia, the ptO2 at 100 μm depth fell rapidly to less than 20 mm Hg. During reoxygenation, large transient ptO2 increases above normoxic values were observed. These data demonstrate that ptO2 'overshoots' occur independently of in situ posthypoxic hyperemia and may reflect pathologic chemical reactions in brain tissue during reoxygenation.
AB - Tissue oxygen pressure (ptO2) was measured with noble metal microelectrodes in hippocampal slices in vitro. During hypoxia, the ptO2 at 100 μm depth fell rapidly to less than 20 mm Hg. During reoxygenation, large transient ptO2 increases above normoxic values were observed. These data demonstrate that ptO2 'overshoots' occur independently of in situ posthypoxic hyperemia and may reflect pathologic chemical reactions in brain tissue during reoxygenation.
UR - http://www.scopus.com/inward/record.url?scp=0022007367&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022007367&partnerID=8YFLogxK
U2 - 10.1016/0006-8993(85)91200-4
DO - 10.1016/0006-8993(85)91200-4
M3 - Article
C2 - 4041862
AN - SCOPUS:0022007367
VL - 344
SP - 150
EP - 153
JO - Brain Research
JF - Brain Research
SN - 0006-8993
IS - 1
ER -