Overshoot of oxygen pressure in post-hypoxic brain tissue: a re-evaluation

Steven J. Schiff; George G. Somjen

doi:10.1016/0006-8993(85)91200-4

Overshoot of oxygen pressure in post-hypoxic brain tissue: a re-evaluation

Steven J. Schiff, George G. Somjen

Research output: Contribution to journal › Article

10 Scopus citations

Abstract

Tissue oxygen pressure (p_tO₂) was measured with noble metal microelectrodes in hippocampal slices in vitro. During hypoxia, the p_tO₂ at 100 μm depth fell rapidly to less than 20 mm Hg. During reoxygenation, large transient p_tO₂ increases above normoxic values were observed. These data demonstrate that p_tO₂ 'overshoots' occur independently of in situ posthypoxic hyperemia and may reflect pathologic chemical reactions in brain tissue during reoxygenation.

Original language	English (US)
Pages (from-to)	150-153
Number of pages	4
Journal	Brain research
Volume	344
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(85)91200-4
State	Published - Sep 30 1985

All Science Journal Classification (ASJC) codes

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(85)91200-4

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Schiff, S. J., & Somjen, G. G. (1985). Overshoot of oxygen pressure in post-hypoxic brain tissue: a re-evaluation. Brain research, 344(1), 150-153. https://doi.org/10.1016/0006-8993(85)91200-4

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abstract = "Tissue oxygen pressure (ptO2) was measured with noble metal microelectrodes in hippocampal slices in vitro. During hypoxia, the ptO2 at 100 μm depth fell rapidly to less than 20 mm Hg. During reoxygenation, large transient ptO2 increases above normoxic values were observed. These data demonstrate that ptO2 'overshoots' occur independently of in situ posthypoxic hyperemia and may reflect pathologic chemical reactions in brain tissue during reoxygenation.",

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