Overshoot of oxygen pressure in post-hypoxic brain tissue: a re-evaluation

Steven Schiff, George G. Somjen

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Tissue oxygen pressure (ptO2) was measured with noble metal microelectrodes in hippocampal slices in vitro. During hypoxia, the ptO2 at 100 μm depth fell rapidly to less than 20 mm Hg. During reoxygenation, large transient ptO2 increases above normoxic values were observed. These data demonstrate that ptO2 'overshoots' occur independently of in situ posthypoxic hyperemia and may reflect pathologic chemical reactions in brain tissue during reoxygenation.

Original languageEnglish (US)
Pages (from-to)150-153
Number of pages4
JournalBrain research
Volume344
Issue number1
DOIs
StatePublished - Sep 30 1985

Fingerprint

Oxygen
Pressure
Brain
Hyperemia
Microelectrodes
Metals
platinum oxide
In Vitro Techniques
Hypoxia

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Cite this

@article{34345263409249a2b8e2f7379375f7e2,
title = "Overshoot of oxygen pressure in post-hypoxic brain tissue: a re-evaluation",
abstract = "Tissue oxygen pressure (ptO2) was measured with noble metal microelectrodes in hippocampal slices in vitro. During hypoxia, the ptO2 at 100 μm depth fell rapidly to less than 20 mm Hg. During reoxygenation, large transient ptO2 increases above normoxic values were observed. These data demonstrate that ptO2 'overshoots' occur independently of in situ posthypoxic hyperemia and may reflect pathologic chemical reactions in brain tissue during reoxygenation.",
author = "Steven Schiff and Somjen, {George G.}",
year = "1985",
month = "9",
day = "30",
doi = "10.1016/0006-8993(85)91200-4",
language = "English (US)",
volume = "344",
pages = "150--153",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier",
number = "1",

}

Overshoot of oxygen pressure in post-hypoxic brain tissue : a re-evaluation. / Schiff, Steven; Somjen, George G.

In: Brain research, Vol. 344, No. 1, 30.09.1985, p. 150-153.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Overshoot of oxygen pressure in post-hypoxic brain tissue

T2 - a re-evaluation

AU - Schiff, Steven

AU - Somjen, George G.

PY - 1985/9/30

Y1 - 1985/9/30

N2 - Tissue oxygen pressure (ptO2) was measured with noble metal microelectrodes in hippocampal slices in vitro. During hypoxia, the ptO2 at 100 μm depth fell rapidly to less than 20 mm Hg. During reoxygenation, large transient ptO2 increases above normoxic values were observed. These data demonstrate that ptO2 'overshoots' occur independently of in situ posthypoxic hyperemia and may reflect pathologic chemical reactions in brain tissue during reoxygenation.

AB - Tissue oxygen pressure (ptO2) was measured with noble metal microelectrodes in hippocampal slices in vitro. During hypoxia, the ptO2 at 100 μm depth fell rapidly to less than 20 mm Hg. During reoxygenation, large transient ptO2 increases above normoxic values were observed. These data demonstrate that ptO2 'overshoots' occur independently of in situ posthypoxic hyperemia and may reflect pathologic chemical reactions in brain tissue during reoxygenation.

UR - http://www.scopus.com/inward/record.url?scp=0022007367&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022007367&partnerID=8YFLogxK

U2 - 10.1016/0006-8993(85)91200-4

DO - 10.1016/0006-8993(85)91200-4

M3 - Article

C2 - 4041862

AN - SCOPUS:0022007367

VL - 344

SP - 150

EP - 153

JO - Brain Research

JF - Brain Research

SN - 0006-8993

IS - 1

ER -