Ovulation detection methods for urinary hormones

Precision, daily and intermittent sampling and a combined hierarchical method

K. A. O'Connor, E. Brindle, R. C. Miller, J. B. Shofer, R. J. Ferrell, N. A. Klein, M. R. Soules, D. J. Holman, P. K. Mansfield, James William Wood

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Background: We evaluate the performance of ovulation detection methods and present new approaches, including evaluation of methods for precision, combining multiple markers into a hierarchical system and using ovulation markers in intermittent sampling designs. Methods: With serum LH peak day as the 'gold standard' of ovulation, we estimated accuracy and precision of ovulation day algorithms using 30 ovulatory menstrual cycles with daily urinary and serum hormones and transvaginal ultrasound. Sensitivity and specificity for estimating the presence of ovulation were tested using visually assessed ovulatory (30) and anovulatory (22) cycles. Results: Sensitivity and specificity ranged from 70 to 100% for estimating presence of ovulation with twice-per-cycle, weekly, twice weekly, every-other-day and daily specimens. A combined hierarchical method estimated ovulation day using daily specimens within ±2 days of the gold standard in 93% of cases. Accuracy of estimating ovulation day within ±2 days using intermittent sampling ranged from 40% (weekly sampling) to 97% (every-other-day). Conclusion: A combined hierarchical algorithm using precise and accurate markers allows maximal use of available data for efficient and objective identification of ovulation using daily specimens. In intermittent sampling designs, the presence and the timing of ovulation can be estimated with good sensitivity, specificity and accuracy.

Original languageEnglish (US)
Pages (from-to)1442-1452
Number of pages11
JournalHuman Reproduction
Volume21
Issue number6
DOIs
StatePublished - Jan 1 2006

Fingerprint

Ovulation Detection
Ovulation
Hormones
Sensitivity and Specificity
Menstrual Cycle
Serum

All Science Journal Classification (ASJC) codes

  • Reproductive Medicine
  • Obstetrics and Gynecology

Cite this

O'Connor, K. A., Brindle, E., Miller, R. C., Shofer, J. B., Ferrell, R. J., Klein, N. A., ... Wood, J. W. (2006). Ovulation detection methods for urinary hormones: Precision, daily and intermittent sampling and a combined hierarchical method. Human Reproduction, 21(6), 1442-1452. https://doi.org/10.1093/humrep/dei497
O'Connor, K. A. ; Brindle, E. ; Miller, R. C. ; Shofer, J. B. ; Ferrell, R. J. ; Klein, N. A. ; Soules, M. R. ; Holman, D. J. ; Mansfield, P. K. ; Wood, James William. / Ovulation detection methods for urinary hormones : Precision, daily and intermittent sampling and a combined hierarchical method. In: Human Reproduction. 2006 ; Vol. 21, No. 6. pp. 1442-1452.
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O'Connor, KA, Brindle, E, Miller, RC, Shofer, JB, Ferrell, RJ, Klein, NA, Soules, MR, Holman, DJ, Mansfield, PK & Wood, JW 2006, 'Ovulation detection methods for urinary hormones: Precision, daily and intermittent sampling and a combined hierarchical method', Human Reproduction, vol. 21, no. 6, pp. 1442-1452. https://doi.org/10.1093/humrep/dei497

Ovulation detection methods for urinary hormones : Precision, daily and intermittent sampling and a combined hierarchical method. / O'Connor, K. A.; Brindle, E.; Miller, R. C.; Shofer, J. B.; Ferrell, R. J.; Klein, N. A.; Soules, M. R.; Holman, D. J.; Mansfield, P. K.; Wood, James William.

In: Human Reproduction, Vol. 21, No. 6, 01.01.2006, p. 1442-1452.

Research output: Contribution to journalArticle

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AU - O'Connor, K. A.

AU - Brindle, E.

AU - Miller, R. C.

AU - Shofer, J. B.

AU - Ferrell, R. J.

AU - Klein, N. A.

AU - Soules, M. R.

AU - Holman, D. J.

AU - Mansfield, P. K.

AU - Wood, James William

PY - 2006/1/1

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N2 - Background: We evaluate the performance of ovulation detection methods and present new approaches, including evaluation of methods for precision, combining multiple markers into a hierarchical system and using ovulation markers in intermittent sampling designs. Methods: With serum LH peak day as the 'gold standard' of ovulation, we estimated accuracy and precision of ovulation day algorithms using 30 ovulatory menstrual cycles with daily urinary and serum hormones and transvaginal ultrasound. Sensitivity and specificity for estimating the presence of ovulation were tested using visually assessed ovulatory (30) and anovulatory (22) cycles. Results: Sensitivity and specificity ranged from 70 to 100% for estimating presence of ovulation with twice-per-cycle, weekly, twice weekly, every-other-day and daily specimens. A combined hierarchical method estimated ovulation day using daily specimens within ±2 days of the gold standard in 93% of cases. Accuracy of estimating ovulation day within ±2 days using intermittent sampling ranged from 40% (weekly sampling) to 97% (every-other-day). Conclusion: A combined hierarchical algorithm using precise and accurate markers allows maximal use of available data for efficient and objective identification of ovulation using daily specimens. In intermittent sampling designs, the presence and the timing of ovulation can be estimated with good sensitivity, specificity and accuracy.

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