Abstract
Asthma is a complex inflammatory disease characterized by airway inflammation and hyperresponsiveness. The mechanisms associated with the development and progression of asthma have been widely studied in multiple populations and animal models, and these have revealed involvement of various cell types and activation of intracellular signaling pathways that result in activation of inflammatory genes. Significant contributions of Toll-like-receptors (TLRs) and transcription factors such as NF-кB, have been reported as major contributors to inflammatory pathways. These have also recently been associated with mechanisms of oxidative biology. This is of important clinical significance as the observed inefficacy of current available treatments for severe asthma is widely attributed to oxidative stress. Therefore, targeting oxidizing molecules in conjunction with inflammatory mediators and transcription factors may present a novel therapeutic strategy for asthma. In this review, we summarize TLRs and NF-кB pathways in the context of exacerbation of asthma pathogenesis and oxidative biology, and we discuss the potential use of polyphenolic flavonoid compounds, known to target these pathways and possess antioxidant activity, as potential therapeutic agents for asthma.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 169-182 |
| Number of pages | 14 |
| Journal | Pharmacology and Therapeutics |
| Volume | 181 |
| DOIs | |
| State | Published - Jan 2018 |
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All Science Journal Classification (ASJC) codes
- Pharmacology
- Pharmacology (medical)
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Oxidative stress and cellular pathways of asthma and inflammation : Therapeutic strategies and pharmacological targets. / Mishra, Vikas; Banga, Jaspreet; Silveyra, Patricia.
In: Pharmacology and Therapeutics, Vol. 181, 01.2018, p. 169-182.Research output: Contribution to journal › Review article
TY - JOUR
T1 - Oxidative stress and cellular pathways of asthma and inflammation
T2 - Therapeutic strategies and pharmacological targets
AU - Mishra, Vikas
AU - Banga, Jaspreet
AU - Silveyra, Patricia
PY - 2018/1
Y1 - 2018/1
N2 - Asthma is a complex inflammatory disease characterized by airway inflammation and hyperresponsiveness. The mechanisms associated with the development and progression of asthma have been widely studied in multiple populations and animal models, and these have revealed involvement of various cell types and activation of intracellular signaling pathways that result in activation of inflammatory genes. Significant contributions of Toll-like-receptors (TLRs) and transcription factors such as NF-кB, have been reported as major contributors to inflammatory pathways. These have also recently been associated with mechanisms of oxidative biology. This is of important clinical significance as the observed inefficacy of current available treatments for severe asthma is widely attributed to oxidative stress. Therefore, targeting oxidizing molecules in conjunction with inflammatory mediators and transcription factors may present a novel therapeutic strategy for asthma. In this review, we summarize TLRs and NF-кB pathways in the context of exacerbation of asthma pathogenesis and oxidative biology, and we discuss the potential use of polyphenolic flavonoid compounds, known to target these pathways and possess antioxidant activity, as potential therapeutic agents for asthma.
AB - Asthma is a complex inflammatory disease characterized by airway inflammation and hyperresponsiveness. The mechanisms associated with the development and progression of asthma have been widely studied in multiple populations and animal models, and these have revealed involvement of various cell types and activation of intracellular signaling pathways that result in activation of inflammatory genes. Significant contributions of Toll-like-receptors (TLRs) and transcription factors such as NF-кB, have been reported as major contributors to inflammatory pathways. These have also recently been associated with mechanisms of oxidative biology. This is of important clinical significance as the observed inefficacy of current available treatments for severe asthma is widely attributed to oxidative stress. Therefore, targeting oxidizing molecules in conjunction with inflammatory mediators and transcription factors may present a novel therapeutic strategy for asthma. In this review, we summarize TLRs and NF-кB pathways in the context of exacerbation of asthma pathogenesis and oxidative biology, and we discuss the potential use of polyphenolic flavonoid compounds, known to target these pathways and possess antioxidant activity, as potential therapeutic agents for asthma.
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UR - http://www.scopus.com/inward/citedby.url?scp=85028326516&partnerID=8YFLogxK
U2 - 10.1016/j.pharmthera.2017.08.011
DO - 10.1016/j.pharmthera.2017.08.011
M3 - Review article
C2 - 28842273
AN - SCOPUS:85028326516
VL - 181
SP - 169
EP - 182
JO - Pharmacology and Therapeutics
JF - Pharmacology and Therapeutics
SN - 0163-7258
ER -