Oxidative stress and cellular pathways of asthma and inflammation: Therapeutic strategies and pharmacological targets

Vikas Mishra, Jaspreet Banga, Patricia Silveyra

Research output: Contribution to journalReview article

21 Citations (Scopus)

Abstract

Asthma is a complex inflammatory disease characterized by airway inflammation and hyperresponsiveness. The mechanisms associated with the development and progression of asthma have been widely studied in multiple populations and animal models, and these have revealed involvement of various cell types and activation of intracellular signaling pathways that result in activation of inflammatory genes. Significant contributions of Toll-like-receptors (TLRs) and transcription factors such as NF-кB, have been reported as major contributors to inflammatory pathways. These have also recently been associated with mechanisms of oxidative biology. This is of important clinical significance as the observed inefficacy of current available treatments for severe asthma is widely attributed to oxidative stress. Therefore, targeting oxidizing molecules in conjunction with inflammatory mediators and transcription factors may present a novel therapeutic strategy for asthma. In this review, we summarize TLRs and NF-кB pathways in the context of exacerbation of asthma pathogenesis and oxidative biology, and we discuss the potential use of polyphenolic flavonoid compounds, known to target these pathways and possess antioxidant activity, as potential therapeutic agents for asthma.

Original languageEnglish (US)
Pages (from-to)169-182
Number of pages14
JournalPharmacology and Therapeutics
Volume181
DOIs
StatePublished - Jan 2018

Fingerprint

Oxidative Stress
Asthma
Pharmacology
Inflammation
Toll-Like Receptors
Transcription Factors
Therapeutics
Flavonoids
Transcriptional Activation
Animal Models
Antioxidants
Population

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)

Cite this

@article{fbe6c31b21d44ab6b15757f8401654d1,
title = "Oxidative stress and cellular pathways of asthma and inflammation: Therapeutic strategies and pharmacological targets",
abstract = "Asthma is a complex inflammatory disease characterized by airway inflammation and hyperresponsiveness. The mechanisms associated with the development and progression of asthma have been widely studied in multiple populations and animal models, and these have revealed involvement of various cell types and activation of intracellular signaling pathways that result in activation of inflammatory genes. Significant contributions of Toll-like-receptors (TLRs) and transcription factors such as NF-кB, have been reported as major contributors to inflammatory pathways. These have also recently been associated with mechanisms of oxidative biology. This is of important clinical significance as the observed inefficacy of current available treatments for severe asthma is widely attributed to oxidative stress. Therefore, targeting oxidizing molecules in conjunction with inflammatory mediators and transcription factors may present a novel therapeutic strategy for asthma. In this review, we summarize TLRs and NF-кB pathways in the context of exacerbation of asthma pathogenesis and oxidative biology, and we discuss the potential use of polyphenolic flavonoid compounds, known to target these pathways and possess antioxidant activity, as potential therapeutic agents for asthma.",
author = "Vikas Mishra and Jaspreet Banga and Patricia Silveyra",
year = "2018",
month = "1",
doi = "10.1016/j.pharmthera.2017.08.011",
language = "English (US)",
volume = "181",
pages = "169--182",
journal = "Pharmacology and Therapeutics",
issn = "0163-7258",
publisher = "Elsevier Inc.",

}

Oxidative stress and cellular pathways of asthma and inflammation : Therapeutic strategies and pharmacological targets. / Mishra, Vikas; Banga, Jaspreet; Silveyra, Patricia.

In: Pharmacology and Therapeutics, Vol. 181, 01.2018, p. 169-182.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Oxidative stress and cellular pathways of asthma and inflammation

T2 - Therapeutic strategies and pharmacological targets

AU - Mishra, Vikas

AU - Banga, Jaspreet

AU - Silveyra, Patricia

PY - 2018/1

Y1 - 2018/1

N2 - Asthma is a complex inflammatory disease characterized by airway inflammation and hyperresponsiveness. The mechanisms associated with the development and progression of asthma have been widely studied in multiple populations and animal models, and these have revealed involvement of various cell types and activation of intracellular signaling pathways that result in activation of inflammatory genes. Significant contributions of Toll-like-receptors (TLRs) and transcription factors such as NF-кB, have been reported as major contributors to inflammatory pathways. These have also recently been associated with mechanisms of oxidative biology. This is of important clinical significance as the observed inefficacy of current available treatments for severe asthma is widely attributed to oxidative stress. Therefore, targeting oxidizing molecules in conjunction with inflammatory mediators and transcription factors may present a novel therapeutic strategy for asthma. In this review, we summarize TLRs and NF-кB pathways in the context of exacerbation of asthma pathogenesis and oxidative biology, and we discuss the potential use of polyphenolic flavonoid compounds, known to target these pathways and possess antioxidant activity, as potential therapeutic agents for asthma.

AB - Asthma is a complex inflammatory disease characterized by airway inflammation and hyperresponsiveness. The mechanisms associated with the development and progression of asthma have been widely studied in multiple populations and animal models, and these have revealed involvement of various cell types and activation of intracellular signaling pathways that result in activation of inflammatory genes. Significant contributions of Toll-like-receptors (TLRs) and transcription factors such as NF-кB, have been reported as major contributors to inflammatory pathways. These have also recently been associated with mechanisms of oxidative biology. This is of important clinical significance as the observed inefficacy of current available treatments for severe asthma is widely attributed to oxidative stress. Therefore, targeting oxidizing molecules in conjunction with inflammatory mediators and transcription factors may present a novel therapeutic strategy for asthma. In this review, we summarize TLRs and NF-кB pathways in the context of exacerbation of asthma pathogenesis and oxidative biology, and we discuss the potential use of polyphenolic flavonoid compounds, known to target these pathways and possess antioxidant activity, as potential therapeutic agents for asthma.

UR - http://www.scopus.com/inward/record.url?scp=85028326516&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85028326516&partnerID=8YFLogxK

U2 - 10.1016/j.pharmthera.2017.08.011

DO - 10.1016/j.pharmthera.2017.08.011

M3 - Review article

C2 - 28842273

AN - SCOPUS:85028326516

VL - 181

SP - 169

EP - 182

JO - Pharmacology and Therapeutics

JF - Pharmacology and Therapeutics

SN - 0163-7258

ER -