Oxytocin pathways in the intergenerational transmission of maternal early life stress

Philipp Toepfer, Christine Heim, Sonja Entringer, Elisabeth Binder, Pathik Wadhwa, Claudia Buss

Research output: Contribution to journalReview article

28 Citations (Scopus)

Abstract

Severe stress in early life, such as childhood abuse and neglect, constitutes a major risk factor in the etiology of psychiatric disorders and somatic diseases. Importantly, these long-term effects may impact the next generation. The intergenerational transmission of maternal early life stress (ELS) may occur via pre-and postnatal pathways, such as alterations in maternal-fetal-placental stress physiology, maternal depression during pregnancy and postpartum, as well as impaired mother-offspring interactions. The neuropeptide oxytocin (OT) has gained considerable attention for its role in modulating all of these assumed transmission pathways. Moreover, central and peripheral OT signaling pathways are highly sensitive to environmental exposures and may be compromised by ELS with implications for these putative transmission mechanisms. Together, these data suggest that OT pathways play an important role in the intergenerational transmission of maternal ELS in humans. By integrating recent studies on gene-environment interactions and epigenetic modifications in OT pathway genes, the present review aims to develop a conceptual framework of intergenerational transmission of maternal ELS that emphasizes the role of OT.

Original languageEnglish (US)
Pages (from-to)293-308
Number of pages16
JournalNeuroscience and Biobehavioral Reviews
Volume73
DOIs
StatePublished - Feb 1 2017

Fingerprint

Oxytocin
Psychological Stress
Mothers
Gene-Environment Interaction
Environmental Exposure
Neuropeptides
Epigenomics
Postpartum Period
Psychiatry
Depression
Pregnancy
Genes

All Science Journal Classification (ASJC) codes

  • Neuropsychology and Physiological Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience

Cite this

Toepfer, Philipp ; Heim, Christine ; Entringer, Sonja ; Binder, Elisabeth ; Wadhwa, Pathik ; Buss, Claudia. / Oxytocin pathways in the intergenerational transmission of maternal early life stress. In: Neuroscience and Biobehavioral Reviews. 2017 ; Vol. 73. pp. 293-308.
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Oxytocin pathways in the intergenerational transmission of maternal early life stress. / Toepfer, Philipp; Heim, Christine; Entringer, Sonja; Binder, Elisabeth; Wadhwa, Pathik; Buss, Claudia.

In: Neuroscience and Biobehavioral Reviews, Vol. 73, 01.02.2017, p. 293-308.

Research output: Contribution to journalReview article

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