p53 Mutations in Nonmelanoma Skin Cancer of the Head and Neck: Molecular Evidence for Field Cancerization

Sagarika Kanjilal, Sara S. Strom, Gary L. Clayman, Randal S. Weber, Adel K. El-Naggar, Vivek Kapur, Kathleen K. Cummings, Leigh Anne Hill, Margaret R. Spitz, Margaret L. Kripke, Honnavara N. Ananthaswamy

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139 Scopus citations

Abstract

multiple and distinct p53 mutations were detected by DNA sequence analysis in tumor and adjacent nonmalignant skin samples from eight patients with nonmelanoma skin cancer of the head and neck, providing unambiguous evidence for field cancerization. The mutations consisted of C→T transitions at dipyrimidine sequences (50% of all single base substitutions), T→C transitions (47%), and G→T transversions (12%), suggesting that other carcinogens may act along with UV radiation in the development of nonmelanoma skin cancer. Patient interviews revealed that, in addition to substantial exposure to solar UV radiation, most had a history of smoking and were exposed to carcinogens from industrial or agricultural sources. These data show that extensive molecular epidemiological investigations are necessary to elucidate risk factors associated with the disease in localities where patients often report substantial exposure to environmental carcinogens.

Original languageEnglish (US)
Pages (from-to)3604-3609
Number of pages6
JournalCancer Research
Volume55
Issue number16
StatePublished - Aug 15 1995

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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    Kanjilal, S., Strom, S. S., Clayman, G. L., Weber, R. S., El-Naggar, A. K., Kapur, V., Cummings, K. K., Hill, L. A., Spitz, M. R., Kripke, M. L., & Ananthaswamy, H. N. (1995). p53 Mutations in Nonmelanoma Skin Cancer of the Head and Neck: Molecular Evidence for Field Cancerization. Cancer Research, 55(16), 3604-3609.