P53 protein overexpression in lung adenocarcinomas in non-smokers: Possible association with environmental tobacco smoke

Joshua E. Muscat, Marc Citron, C. X. Wang, Agnes White, Philip Lazarus

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Greater than 55% of all lung cancers contain mutations in the p53 tumor suppressor gene, and the frequency of p53 mutations has been directly correlated with the use of tobacco and the smoking of cigarettes. To determine if environmental tobacco smoke (ETS) is associated with changes in p53 expression in human lung cancer in never-smokers, we determined the degree of p53 protein expression in ten lung tumors from never-smokers exposed to ETS. We show that 5 of 8 (62.5%) adenocarcinomas contained significant levels of p53 protein over-expression as detected by immunohistochemical staining. While these findings suggest that ETS is a possible inducer of altered p53 expression in lung adenocarcinoma in non- smokers, larger studies are needed to confirm this relationship.

Original languageEnglish (US)
Pages (from-to)825-827
Number of pages3
JournalOncology reports
Volume4
Issue number4
StatePublished - Jul 1 1997

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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