Palatability and body fluid homeostasis

Barbara Jean Rolls, Roger J. Wood, Richard M. Stevens

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

The results show that rats drink large volumes of a palatable saccharine solution and rely on the kidneys to eliminate excess water. Rats in fluid balance at the start of the experiment overdrink sodium saccharine (0.005 M) and go significantly into positive fluid balance. If the kidneys are functioning normally the maximum change in fluid balance occurs one half hour after the start of drinking (plasma osmolality is decreased by 9 m osm/kg H2O). The production of a hypotonic urine rapidly restores the plasma to more normal levels. If rats are injected with antidiuretic hormone so that a hypotonic urine cannot be produced, drinking persists in spite of significant plasma dilution. After 3 hr plasma osmolality is reduced by 22 m osm/kg H2O (p<0.001), plasma sodium is reduced by 8 m equiv/L (p<0.001) and plasma protein is reduced by 0.4 g% (p<0.05). At this point saccharine consumption decreases but does not stop. The rats showed signs of ill health and subsequent transitory aversion to saccharine. Thus if renal function is impaired, palatability can lead to severe overhydration and hyponatremia.

Original languageEnglish (US)
Pages (from-to)15-19
Number of pages5
JournalPhysiology and Behavior
Volume20
Issue number1
DOIs
StatePublished - Jan 1 1978

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Body Fluids
Homeostasis
Water-Electrolyte Balance
Kidney
Osmolar Concentration
Drinking
Sodium
Urine
Hyponatremia
Vasopressins
Blood Proteins
Water
Health

All Science Journal Classification (ASJC) codes

  • Experimental and Cognitive Psychology
  • Behavioral Neuroscience

Cite this

Rolls, Barbara Jean ; Wood, Roger J. ; Stevens, Richard M. / Palatability and body fluid homeostasis. In: Physiology and Behavior. 1978 ; Vol. 20, No. 1. pp. 15-19.
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Palatability and body fluid homeostasis. / Rolls, Barbara Jean; Wood, Roger J.; Stevens, Richard M.

In: Physiology and Behavior, Vol. 20, No. 1, 01.01.1978, p. 15-19.

Research output: Contribution to journalArticle

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