Palladium-catalyzed alkenylation and alkynylation of ortho-C(sp 2)-H bonds of benzylamine picolinamides

Yingsheng Zhao, Gang He, William A. Nack, Gong Chen

Research output: Contribution to journalArticlepeer-review

71 Scopus citations


An efficient functionalization of ortho-C(sp 2)-H bonds of picolinamide (PA)-protected benzylamine substrates with a range of vinyl iodides as well as acetylenic bromide is reported. ortho-Phenyl benzoic acid (oPBA) acts as an effective promoter in this reaction system. This method provides a practical strategy to access highly functionalized benzylamine compounds for organic synthesis.

Original languageEnglish (US)
Pages (from-to)2948-2951
Number of pages4
JournalOrganic Letters
Issue number12
StatePublished - Jun 15 2012

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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