Abstract
A new protocol for Pd-catalyzed β methylene C-H arylation of N-quinolyl cycloalkylcarboxamides with aryl iodides at room temperature is reported. The β methylene C-H bonds of symmetrical cycloalkylcarboxamides of varied ring size can be arylated in moderate to good yields and monoselectivity with excellent diastereoselectivity. This mono-selective β methylene C-H arylation reaction enabled the rapid synthesis of complex carbocycle products from easily accessible symmetrical cycloalkyl carboxylic acids via sequential C-H functionalization.
Original language | English (US) |
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Pages (from-to) | 561-564 |
Number of pages | 4 |
Journal | Organic Chemistry Frontiers |
Volume | 3 |
Issue number | 5 |
DOIs | |
State | Published - May 2016 |
All Science Journal Classification (ASJC) codes
- Organic Chemistry