Palladium-catalyzed methylation and arylation of sp2 and sp 3 C-H bonds in simple carboxylic acids

Ramesh Giri, Nathan Maugel, Jiao Jie Li, Dong Hui Wang, Steven P. Breazzano, Lindsey B. Saunders, Jin Quan Yu

Research output: Contribution to journalArticlepeer-review

582 Scopus citations


The use of preformed sodium carboxylates as substrates led to the first observation of facile Pd-insertions into sp3 β-C-H bonds in simple aliphatic acids. Consequently, Pd-catalyzed methylation and arylation of o-C-H bonds in benzoic acids and β-C-H bonds in aliphatic acids using either a phenylboronate, methylboronic acid, or ArI have been achieved via a C-H activation/C-C coupling sequence.

Original languageEnglish (US)
Pages (from-to)3510-3511
Number of pages2
JournalJournal of the American Chemical Society
Issue number12
StatePublished - Mar 28 2007

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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