Palladium-Catalyzed ortho C−H Arylation of Benzaldehydes Using ortho-Sulfinyl Aniline as Transient Auxiliary

Delong Mu, Gang He, Gong Chen

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A PdII-catalyzed ortho-(Csp2)–H arylation reaction of benzaldehydes using a catalytic amount of 2-(methylsulfinyl)aniline as transient auxiliary was developed. This reaction is compatible with a broad range of benzaldehyde and aryl iodide substrates. Compared with other related reaction systems, an excellent regioselectivity for ortho-C(sp2)−H bonds over benzylic C(sp3)−H bonds was obtained for ortho-alkyl-benzaldehyde substrates.

Original languageEnglish (US)
Pages (from-to)2423-2426
Number of pages4
JournalChemistry - An Asian Journal
Volume13
Issue number17
DOIs
StatePublished - Sep 4 2018

Fingerprint

Benzaldehydes
Palladium
Regioselectivity
Iodides
Substrates
aniline
benzaldehyde

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Biochemistry
  • Organic Chemistry

Cite this

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abstract = "A PdII-catalyzed ortho-(Csp2)–H arylation reaction of benzaldehydes using a catalytic amount of 2-(methylsulfinyl)aniline as transient auxiliary was developed. This reaction is compatible with a broad range of benzaldehyde and aryl iodide substrates. Compared with other related reaction systems, an excellent regioselectivity for ortho-C(sp2)−H bonds over benzylic C(sp3)−H bonds was obtained for ortho-alkyl-benzaldehyde substrates.",
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Palladium-Catalyzed ortho C−H Arylation of Benzaldehydes Using ortho-Sulfinyl Aniline as Transient Auxiliary. / Mu, Delong; He, Gang; Chen, Gong.

In: Chemistry - An Asian Journal, Vol. 13, No. 17, 04.09.2018, p. 2423-2426.

Research output: Contribution to journalArticle

TY - JOUR

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AU - He, Gang

AU - Chen, Gong

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AB - A PdII-catalyzed ortho-(Csp2)–H arylation reaction of benzaldehydes using a catalytic amount of 2-(methylsulfinyl)aniline as transient auxiliary was developed. This reaction is compatible with a broad range of benzaldehyde and aryl iodide substrates. Compared with other related reaction systems, an excellent regioselectivity for ortho-C(sp2)−H bonds over benzylic C(sp3)−H bonds was obtained for ortho-alkyl-benzaldehyde substrates.

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