Palladium-Catalyzed ortho C−H Arylation of Benzaldehydes Using ortho-Sulfinyl Aniline as Transient Auxiliary

Delong Mu, Gang He, Gong Chen

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

A PdII-catalyzed ortho-(Csp2)–H arylation reaction of benzaldehydes using a catalytic amount of 2-(methylsulfinyl)aniline as transient auxiliary was developed. This reaction is compatible with a broad range of benzaldehyde and aryl iodide substrates. Compared with other related reaction systems, an excellent regioselectivity for ortho-C(sp2)−H bonds over benzylic C(sp3)−H bonds was obtained for ortho-alkyl-benzaldehyde substrates.

Original languageEnglish (US)
Pages (from-to)2423-2426
Number of pages4
JournalChemistry - An Asian Journal
Volume13
Issue number17
DOIs
StatePublished - Sep 4 2018

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Organic Chemistry

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