Panax ginseng has anti-infective activity against opportunistic pathogen Pseudomonas aeruginosa by inhibiting quorum sensing, a bacterial communication process critical for establishing infection

Z. Song, K. F. Kong, H. Wu, N. Maricic, B. Ramalingam, H. Priestap, L. Schneper, J. M.E. Quirke, N. Høiby, K. Mathee

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Virulent factors produced by pathogens play an important role in the infectious process, which is regulated by a cell-to-cell communication mechanism called quorum sensing (QS). Pseudomonas aeruginosa is an important opportunistic human pathogen, which causes infections in patients with compromised immune systems and cystic fibrosis. The QS systems of P. aeruginosa use N-acylated homoserine lactone (AHL) as signal molecules. Previously we have demonstrated that Panax ginseng treatment allowed the animals with P. aeruginosa pneumonia to effectively clear the bacterial infection. We postulated that the ability to impact the outcome of infections is partly due to ginseng having direct effect on the production of P. aeruginosa virulence factors. The study explores the effect of ginseng on alginate, protease and AHL production. The effect of ginseng extracts on growth and expression of QS-controlled virulence factors on the prototypicP. aeruginosa PAO1 and its isogenic mucoid variant (PAO. mucA22) was determined. Ginseng did not inhibit the growth of the bacteria, enhanced the extracellular protein production and stimulated the production of alginate. However, ginseng suppressed the production of LasA and LasB and down-regulated the synthesis of the AHL molecules. Ginseng has a negative effect on the QS system of P. aeruginosa, may explain the ginseng-dependent bacterial clearance from the animal lungs in vivo in our previous animal study. It is possible that enhancing and repressing activities of ginseng are mutually exclusive as it is a complex mixture, as shown with the HPLC analysis of the hot water extract. Though ginseng is a promising natural synergetic remedy, it is important to isolate and evaluate the ginseng compounds associated with the anti-QS activity.

Original languageEnglish (US)
Pages (from-to)1040-1046
Number of pages7
JournalPhytomedicine
Volume17
Issue number13
DOIs
StatePublished - Nov 1 2010

Fingerprint

Bacterial Physiological Phenomena
Quorum Sensing
Panax
Pseudomonas aeruginosa
Communication
Infection
Acyl-Butyrolactones
Virulence Factors
Aptitude
Growth
Complex Mixtures
Bacterial Infections
Cystic Fibrosis
Cell Communication

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine

Cite this

Song, Z. ; Kong, K. F. ; Wu, H. ; Maricic, N. ; Ramalingam, B. ; Priestap, H. ; Schneper, L. ; Quirke, J. M.E. ; Høiby, N. ; Mathee, K. / Panax ginseng has anti-infective activity against opportunistic pathogen Pseudomonas aeruginosa by inhibiting quorum sensing, a bacterial communication process critical for establishing infection. In: Phytomedicine. 2010 ; Vol. 17, No. 13. pp. 1040-1046.
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Panax ginseng has anti-infective activity against opportunistic pathogen Pseudomonas aeruginosa by inhibiting quorum sensing, a bacterial communication process critical for establishing infection. / Song, Z.; Kong, K. F.; Wu, H.; Maricic, N.; Ramalingam, B.; Priestap, H.; Schneper, L.; Quirke, J. M.E.; Høiby, N.; Mathee, K.

In: Phytomedicine, Vol. 17, No. 13, 01.11.2010, p. 1040-1046.

Research output: Contribution to journalArticle

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