Papillomas and carcinomas in transgenic rabbits carrying EJ-ras DNA and cottontail rabbit papillomavirus DNA

Xuwen Peng, R. O. Olson, C. B. Christian, C. M. Lang, J. W. Kreider

Research output: Contribution to journalComment/debate

19 Citations (Scopus)

Abstract

Two transgenic rabbits (TRI and TRIII) that carried cottontail rabbit papillomavirus (CRPV) DNA alone were identified; another (TRII) carried both CRPV DNA and EJ-ras. TRI and TRIII developed extensive skin papillomas at about 1 month of age, and transcripts of CRPV DNA were detectable only in skin and/or papillomas. TRII developed extensive squamous carcinomas of the skin at a very early age. Transcription of both CRPV DNA and EJ-ras was found in the skin cancers. Thus, the tissue specificity of CRPV DNA expression in transgenic rabbits was the same as in virion-infected animals. The expression of EJ-ras could be dependent on the expression of certain CRPV genes and may be a critical cofactor of CRPV DNA in the progression of carcinomas.

Original languageEnglish (US)
Pages (from-to)1698-1701
Number of pages4
JournalJournal of Virology
Volume67
Issue number3
StatePublished - Jan 1 1993

Fingerprint

Cottontail rabbit papillomavirus
papilloma
Papilloma
carcinoma
rabbits
genetically modified organisms
Rabbits
Carcinoma
DNA
skin (animal)
Skin
Organ Specificity
Skin Neoplasms
virion
Virion
Squamous Cell Carcinoma
transcription (genetics)
gene expression

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

Cite this

Peng, X., Olson, R. O., Christian, C. B., Lang, C. M., & Kreider, J. W. (1993). Papillomas and carcinomas in transgenic rabbits carrying EJ-ras DNA and cottontail rabbit papillomavirus DNA. Journal of Virology, 67(3), 1698-1701.
Peng, Xuwen ; Olson, R. O. ; Christian, C. B. ; Lang, C. M. ; Kreider, J. W. / Papillomas and carcinomas in transgenic rabbits carrying EJ-ras DNA and cottontail rabbit papillomavirus DNA. In: Journal of Virology. 1993 ; Vol. 67, No. 3. pp. 1698-1701.
@article{2ea58acf1fee411091c3312bc85b0a5f,
title = "Papillomas and carcinomas in transgenic rabbits carrying EJ-ras DNA and cottontail rabbit papillomavirus DNA",
abstract = "Two transgenic rabbits (TRI and TRIII) that carried cottontail rabbit papillomavirus (CRPV) DNA alone were identified; another (TRII) carried both CRPV DNA and EJ-ras. TRI and TRIII developed extensive skin papillomas at about 1 month of age, and transcripts of CRPV DNA were detectable only in skin and/or papillomas. TRII developed extensive squamous carcinomas of the skin at a very early age. Transcription of both CRPV DNA and EJ-ras was found in the skin cancers. Thus, the tissue specificity of CRPV DNA expression in transgenic rabbits was the same as in virion-infected animals. The expression of EJ-ras could be dependent on the expression of certain CRPV genes and may be a critical cofactor of CRPV DNA in the progression of carcinomas.",
author = "Xuwen Peng and Olson, {R. O.} and Christian, {C. B.} and Lang, {C. M.} and Kreider, {J. W.}",
year = "1993",
month = "1",
day = "1",
language = "English (US)",
volume = "67",
pages = "1698--1701",
journal = "Journal of Virology",
issn = "0022-538X",
publisher = "American Society for Microbiology",
number = "3",

}

Peng, X, Olson, RO, Christian, CB, Lang, CM & Kreider, JW 1993, 'Papillomas and carcinomas in transgenic rabbits carrying EJ-ras DNA and cottontail rabbit papillomavirus DNA', Journal of Virology, vol. 67, no. 3, pp. 1698-1701.

Papillomas and carcinomas in transgenic rabbits carrying EJ-ras DNA and cottontail rabbit papillomavirus DNA. / Peng, Xuwen; Olson, R. O.; Christian, C. B.; Lang, C. M.; Kreider, J. W.

In: Journal of Virology, Vol. 67, No. 3, 01.01.1993, p. 1698-1701.

Research output: Contribution to journalComment/debate

TY - JOUR

T1 - Papillomas and carcinomas in transgenic rabbits carrying EJ-ras DNA and cottontail rabbit papillomavirus DNA

AU - Peng, Xuwen

AU - Olson, R. O.

AU - Christian, C. B.

AU - Lang, C. M.

AU - Kreider, J. W.

PY - 1993/1/1

Y1 - 1993/1/1

N2 - Two transgenic rabbits (TRI and TRIII) that carried cottontail rabbit papillomavirus (CRPV) DNA alone were identified; another (TRII) carried both CRPV DNA and EJ-ras. TRI and TRIII developed extensive skin papillomas at about 1 month of age, and transcripts of CRPV DNA were detectable only in skin and/or papillomas. TRII developed extensive squamous carcinomas of the skin at a very early age. Transcription of both CRPV DNA and EJ-ras was found in the skin cancers. Thus, the tissue specificity of CRPV DNA expression in transgenic rabbits was the same as in virion-infected animals. The expression of EJ-ras could be dependent on the expression of certain CRPV genes and may be a critical cofactor of CRPV DNA in the progression of carcinomas.

AB - Two transgenic rabbits (TRI and TRIII) that carried cottontail rabbit papillomavirus (CRPV) DNA alone were identified; another (TRII) carried both CRPV DNA and EJ-ras. TRI and TRIII developed extensive skin papillomas at about 1 month of age, and transcripts of CRPV DNA were detectable only in skin and/or papillomas. TRII developed extensive squamous carcinomas of the skin at a very early age. Transcription of both CRPV DNA and EJ-ras was found in the skin cancers. Thus, the tissue specificity of CRPV DNA expression in transgenic rabbits was the same as in virion-infected animals. The expression of EJ-ras could be dependent on the expression of certain CRPV genes and may be a critical cofactor of CRPV DNA in the progression of carcinomas.

UR - http://www.scopus.com/inward/record.url?scp=0027450329&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027450329&partnerID=8YFLogxK

M3 - Comment/debate

C2 - 8382316

AN - SCOPUS:0027450329

VL - 67

SP - 1698

EP - 1701

JO - Journal of Virology

JF - Journal of Virology

SN - 0022-538X

IS - 3

ER -