Abstract
Human papillomaviruses (HPV) contribute to most cervical cancers and are considered to be sexually transmitted. However, papillomaviruses are often found in cancers of internal organs, including the stomach, raising the question as to how the viruses gain access to these sites. A possible connection between blood transfusion and HPV-associated disease has not received much attention. Here we show, in rabbit and mouse models, that blood infected with papillomavirus yields infections at permissive sites with detectable viral DNA, RNA transcripts, and protein products. The rabbit skin tumours induced via blood infection displayed decreased expression of SLN, TAC1, MYH8, PGAM2, and APOBEC2 and increased expression of SDRC7, KRT16, S100A9, IL36G, and FABP9, as seen in tumours induced by local infections. Furthermore, we demonstrate that blood from infected mice can transmit the infection to uninfected animals. Finally, we demonstrate the presence of papillomavirus infections and virus-induced hyperplasia in the stomach tissues of animals infected via the blood. These results indicate that blood transmission could be another route for papillomavirus infection, implying that the human blood supply, which is not screened for papillomaviruses, could be a potential source of HPV infection as well as subsequent cancers in tissues not normally associated with the viruses.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1108-1121 |
| Number of pages | 14 |
| Journal | Emerging Microbes and Infections |
| Volume | 8 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 2019 |
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All Science Journal Classification (ASJC) codes
- Parasitology
- Epidemiology
- Microbiology
- Immunology
- Drug Discovery
- Virology
- Infectious Diseases
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Papillomavirus can be transmitted through the blood and produce infections in blood recipients : Evidence from two animal models. / Cladel, Nancy M.; Jiang, Pengfei; Li, Jingwei J.; Peng, Xuwen; Cooper, Timothy K.; Majerciak, Vladimir; Balogh, Karla K.; Meyer, Thomas J.; Brendle, Sarah A.; Budgeon, Lynn R.; Shearer, Debra A.; Munden, Regina; Cam, Maggie; Vallur, Raghavan; Christensen, Neil D.; Zheng, Zhi Ming; Hu, Jiafen.
In: Emerging Microbes and Infections, Vol. 8, No. 1, 01.01.2019, p. 1108-1121.Research output: Contribution to journal › Article
TY - JOUR
T1 - Papillomavirus can be transmitted through the blood and produce infections in blood recipients
T2 - Evidence from two animal models
AU - Cladel, Nancy M.
AU - Jiang, Pengfei
AU - Li, Jingwei J.
AU - Peng, Xuwen
AU - Cooper, Timothy K.
AU - Majerciak, Vladimir
AU - Balogh, Karla K.
AU - Meyer, Thomas J.
AU - Brendle, Sarah A.
AU - Budgeon, Lynn R.
AU - Shearer, Debra A.
AU - Munden, Regina
AU - Cam, Maggie
AU - Vallur, Raghavan
AU - Christensen, Neil D.
AU - Zheng, Zhi Ming
AU - Hu, Jiafen
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Human papillomaviruses (HPV) contribute to most cervical cancers and are considered to be sexually transmitted. However, papillomaviruses are often found in cancers of internal organs, including the stomach, raising the question as to how the viruses gain access to these sites. A possible connection between blood transfusion and HPV-associated disease has not received much attention. Here we show, in rabbit and mouse models, that blood infected with papillomavirus yields infections at permissive sites with detectable viral DNA, RNA transcripts, and protein products. The rabbit skin tumours induced via blood infection displayed decreased expression of SLN, TAC1, MYH8, PGAM2, and APOBEC2 and increased expression of SDRC7, KRT16, S100A9, IL36G, and FABP9, as seen in tumours induced by local infections. Furthermore, we demonstrate that blood from infected mice can transmit the infection to uninfected animals. Finally, we demonstrate the presence of papillomavirus infections and virus-induced hyperplasia in the stomach tissues of animals infected via the blood. These results indicate that blood transmission could be another route for papillomavirus infection, implying that the human blood supply, which is not screened for papillomaviruses, could be a potential source of HPV infection as well as subsequent cancers in tissues not normally associated with the viruses.
AB - Human papillomaviruses (HPV) contribute to most cervical cancers and are considered to be sexually transmitted. However, papillomaviruses are often found in cancers of internal organs, including the stomach, raising the question as to how the viruses gain access to these sites. A possible connection between blood transfusion and HPV-associated disease has not received much attention. Here we show, in rabbit and mouse models, that blood infected with papillomavirus yields infections at permissive sites with detectable viral DNA, RNA transcripts, and protein products. The rabbit skin tumours induced via blood infection displayed decreased expression of SLN, TAC1, MYH8, PGAM2, and APOBEC2 and increased expression of SDRC7, KRT16, S100A9, IL36G, and FABP9, as seen in tumours induced by local infections. Furthermore, we demonstrate that blood from infected mice can transmit the infection to uninfected animals. Finally, we demonstrate the presence of papillomavirus infections and virus-induced hyperplasia in the stomach tissues of animals infected via the blood. These results indicate that blood transmission could be another route for papillomavirus infection, implying that the human blood supply, which is not screened for papillomaviruses, could be a potential source of HPV infection as well as subsequent cancers in tissues not normally associated with the viruses.
UR - http://www.scopus.com/inward/record.url?scp=85069751830&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85069751830&partnerID=8YFLogxK
U2 - 10.1080/22221751.2019.1637072
DO - 10.1080/22221751.2019.1637072
M3 - Article
C2 - 31340720
AN - SCOPUS:85069751830
VL - 8
SP - 1108
EP - 1121
JO - Emerging Microbes and Infections
JF - Emerging Microbes and Infections
SN - 2222-1751
IS - 1
ER -