TY - JOUR
T1 - Papillomavirus can be transmitted through the blood and produce infections in blood recipients
T2 - Evidence from two animal models
AU - Cladel, Nancy M.
AU - Jiang, Pengfei
AU - Li, Jingwei J.
AU - Peng, Xuwen
AU - Cooper, Timothy K.
AU - Majerciak, Vladimir
AU - Balogh, Karla K.
AU - Meyer, Thomas J.
AU - Brendle, Sarah A.
AU - Budgeon, Lynn R.
AU - Shearer, Debra A.
AU - Munden, Regina
AU - Cam, Maggie
AU - Vallur, Raghavan
AU - Christensen, Neil D.
AU - Zheng, Zhi Ming
AU - Hu, Jiafen
N1 - Funding Information:
Research reported in this publication was supported by the NCI [grant number R01CA47622 to N.C.], NIAID [grant number R21AI121822 to N.C. and J.H.] and the Jake Gittlen Memorial Golf Tournament. This study was also supported by Intramural Research Program of NCI/NIH [grant number 1ZIASC010357 to Z.M.Z.] and NCI/NIH contract [grant number HHSN261200800001E]. Pengfei Jiang was supported by the China Scholarship Council for 1 year study at NIH (CSC NO. 201708330003). The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government. This research was supported (in part) by the National Institutes of Health. We thank Dr. John Doorbar for providing his anti-MmuPV1 E4 antibody. The opinions expressed in this article are the author's own and do not reflect the view of the National Institutes of Health, the Department of Health and Human Services, or the United States government.
Funding Information:
Research reported in this publication was supported by the NCI [grant number R01CA47622 to N.C.], NIAID [grant number R21AI121822 to N.C. and J.H.] and the Jake Gittlen Memorial Golf Tournament. This study was also supported by Intramural Research Program of NCI/NIH [grant number 1ZIASC010357 to Z.M.Z.] and NCI/NIH contract [grant number HHSN261200800001E]. Pengfei Jiang was supported by the China Scholarship Council for 1 year study at NIH (CSC NO. 201708330003). The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government. This research was supported (in part) by the National Institutes of Health.
Publisher Copyright:
© 2019, © 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group, on behalf of Shanghai Shangyixun Cultural Communication Co., Ltd.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Human papillomaviruses (HPV) contribute to most cervical cancers and are considered to be sexually transmitted. However, papillomaviruses are often found in cancers of internal organs, including the stomach, raising the question as to how the viruses gain access to these sites. A possible connection between blood transfusion and HPV-associated disease has not received much attention. Here we show, in rabbit and mouse models, that blood infected with papillomavirus yields infections at permissive sites with detectable viral DNA, RNA transcripts, and protein products. The rabbit skin tumours induced via blood infection displayed decreased expression of SLN, TAC1, MYH8, PGAM2, and APOBEC2 and increased expression of SDRC7, KRT16, S100A9, IL36G, and FABP9, as seen in tumours induced by local infections. Furthermore, we demonstrate that blood from infected mice can transmit the infection to uninfected animals. Finally, we demonstrate the presence of papillomavirus infections and virus-induced hyperplasia in the stomach tissues of animals infected via the blood. These results indicate that blood transmission could be another route for papillomavirus infection, implying that the human blood supply, which is not screened for papillomaviruses, could be a potential source of HPV infection as well as subsequent cancers in tissues not normally associated with the viruses.
AB - Human papillomaviruses (HPV) contribute to most cervical cancers and are considered to be sexually transmitted. However, papillomaviruses are often found in cancers of internal organs, including the stomach, raising the question as to how the viruses gain access to these sites. A possible connection between blood transfusion and HPV-associated disease has not received much attention. Here we show, in rabbit and mouse models, that blood infected with papillomavirus yields infections at permissive sites with detectable viral DNA, RNA transcripts, and protein products. The rabbit skin tumours induced via blood infection displayed decreased expression of SLN, TAC1, MYH8, PGAM2, and APOBEC2 and increased expression of SDRC7, KRT16, S100A9, IL36G, and FABP9, as seen in tumours induced by local infections. Furthermore, we demonstrate that blood from infected mice can transmit the infection to uninfected animals. Finally, we demonstrate the presence of papillomavirus infections and virus-induced hyperplasia in the stomach tissues of animals infected via the blood. These results indicate that blood transmission could be another route for papillomavirus infection, implying that the human blood supply, which is not screened for papillomaviruses, could be a potential source of HPV infection as well as subsequent cancers in tissues not normally associated with the viruses.
UR - http://www.scopus.com/inward/record.url?scp=85069751830&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85069751830&partnerID=8YFLogxK
U2 - 10.1080/22221751.2019.1637072
DO - 10.1080/22221751.2019.1637072
M3 - Article
C2 - 31340720
AN - SCOPUS:85069751830
VL - 8
SP - 1108
EP - 1121
JO - Emerging Microbes and Infections
JF - Emerging Microbes and Infections
SN - 2222-1751
IS - 1
ER -