Papillomavirus can be transmitted through the blood and produce infections in blood recipients: Evidence from two animal models

Nancy M. Cladel, Pengfei Jiang, Jingwei J. Li, Xuwen Peng, Timothy K. Cooper, Vladimir Majerciak, Karla K. Balogh, Thomas J. Meyer, Sarah A. Brendle, Lynn R. Budgeon, Debra A. Shearer, Regina Munden, Maggie Cam, Raghavan Vallur, Neil Christensen, Zhi Ming Zheng, Jiafen Hu

Research output: Contribution to journalArticle

Abstract

Human papillomaviruses (HPV) contribute to most cervical cancers and are considered to be sexually transmitted. However, papillomaviruses are often found in cancers of internal organs, including the stomach, raising the question as to how the viruses gain access to these sites. A possible connection between blood transfusion and HPV-associated disease has not received much attention. Here we show, in rabbit and mouse models, that blood infected with papillomavirus yields infections at permissive sites with detectable viral DNA, RNA transcripts, and protein products. The rabbit skin tumours induced via blood infection displayed decreased expression of SLN, TAC1, MYH8, PGAM2, and APOBEC2 and increased expression of SDRC7, KRT16, S100A9, IL36G, and FABP9, as seen in tumours induced by local infections. Furthermore, we demonstrate that blood from infected mice can transmit the infection to uninfected animals. Finally, we demonstrate the presence of papillomavirus infections and virus-induced hyperplasia in the stomach tissues of animals infected via the blood. These results indicate that blood transmission could be another route for papillomavirus infection, implying that the human blood supply, which is not screened for papillomaviruses, could be a potential source of HPV infection as well as subsequent cancers in tissues not normally associated with the viruses.

Original languageEnglish (US)
Pages (from-to)1108-1121
Number of pages14
JournalEmerging Microbes and Infections
Volume8
Issue number1
DOIs
StatePublished - Jan 1 2019

Fingerprint

Papillomavirus Infections
Animal Models
Infection
Neoplasms
Stomach
Rabbits
Viruses
Satellite Viruses
Viral DNA
Viral RNA
Blood Transfusion
Uterine Cervical Neoplasms
Hyperplasia
Skin
Proteins

All Science Journal Classification (ASJC) codes

  • Parasitology
  • Epidemiology
  • Microbiology
  • Immunology
  • Drug Discovery
  • Virology
  • Infectious Diseases

Cite this

Cladel, Nancy M. ; Jiang, Pengfei ; Li, Jingwei J. ; Peng, Xuwen ; Cooper, Timothy K. ; Majerciak, Vladimir ; Balogh, Karla K. ; Meyer, Thomas J. ; Brendle, Sarah A. ; Budgeon, Lynn R. ; Shearer, Debra A. ; Munden, Regina ; Cam, Maggie ; Vallur, Raghavan ; Christensen, Neil ; Zheng, Zhi Ming ; Hu, Jiafen. / Papillomavirus can be transmitted through the blood and produce infections in blood recipients : Evidence from two animal models. In: Emerging Microbes and Infections. 2019 ; Vol. 8, No. 1. pp. 1108-1121.
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abstract = "Human papillomaviruses (HPV) contribute to most cervical cancers and are considered to be sexually transmitted. However, papillomaviruses are often found in cancers of internal organs, including the stomach, raising the question as to how the viruses gain access to these sites. A possible connection between blood transfusion and HPV-associated disease has not received much attention. Here we show, in rabbit and mouse models, that blood infected with papillomavirus yields infections at permissive sites with detectable viral DNA, RNA transcripts, and protein products. The rabbit skin tumours induced via blood infection displayed decreased expression of SLN, TAC1, MYH8, PGAM2, and APOBEC2 and increased expression of SDRC7, KRT16, S100A9, IL36G, and FABP9, as seen in tumours induced by local infections. Furthermore, we demonstrate that blood from infected mice can transmit the infection to uninfected animals. Finally, we demonstrate the presence of papillomavirus infections and virus-induced hyperplasia in the stomach tissues of animals infected via the blood. These results indicate that blood transmission could be another route for papillomavirus infection, implying that the human blood supply, which is not screened for papillomaviruses, could be a potential source of HPV infection as well as subsequent cancers in tissues not normally associated with the viruses.",
author = "Cladel, {Nancy M.} and Pengfei Jiang and Li, {Jingwei J.} and Xuwen Peng and Cooper, {Timothy K.} and Vladimir Majerciak and Balogh, {Karla K.} and Meyer, {Thomas J.} and Brendle, {Sarah A.} and Budgeon, {Lynn R.} and Shearer, {Debra A.} and Regina Munden and Maggie Cam and Raghavan Vallur and Neil Christensen and Zheng, {Zhi Ming} and Jiafen Hu",
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Cladel, NM, Jiang, P, Li, JJ, Peng, X, Cooper, TK, Majerciak, V, Balogh, KK, Meyer, TJ, Brendle, SA, Budgeon, LR, Shearer, DA, Munden, R, Cam, M, Vallur, R, Christensen, N, Zheng, ZM & Hu, J 2019, 'Papillomavirus can be transmitted through the blood and produce infections in blood recipients: Evidence from two animal models', Emerging Microbes and Infections, vol. 8, no. 1, pp. 1108-1121. https://doi.org/10.1080/22221751.2019.1637072

Papillomavirus can be transmitted through the blood and produce infections in blood recipients : Evidence from two animal models. / Cladel, Nancy M.; Jiang, Pengfei; Li, Jingwei J.; Peng, Xuwen; Cooper, Timothy K.; Majerciak, Vladimir; Balogh, Karla K.; Meyer, Thomas J.; Brendle, Sarah A.; Budgeon, Lynn R.; Shearer, Debra A.; Munden, Regina; Cam, Maggie; Vallur, Raghavan; Christensen, Neil; Zheng, Zhi Ming; Hu, Jiafen.

In: Emerging Microbes and Infections, Vol. 8, No. 1, 01.01.2019, p. 1108-1121.

Research output: Contribution to journalArticle

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T1 - Papillomavirus can be transmitted through the blood and produce infections in blood recipients

T2 - Evidence from two animal models

AU - Cladel, Nancy M.

AU - Jiang, Pengfei

AU - Li, Jingwei J.

AU - Peng, Xuwen

AU - Cooper, Timothy K.

AU - Majerciak, Vladimir

AU - Balogh, Karla K.

AU - Meyer, Thomas J.

AU - Brendle, Sarah A.

AU - Budgeon, Lynn R.

AU - Shearer, Debra A.

AU - Munden, Regina

AU - Cam, Maggie

AU - Vallur, Raghavan

AU - Christensen, Neil

AU - Zheng, Zhi Ming

AU - Hu, Jiafen

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