Papular xanthomas and erosive arthritis in a 3 year old girl, is this a new MRH variant?

Catalina Matiz, Polly J. Ferguson, Andrea Zaenglein, Brandt Groh, Catherine Bingham

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Xanthomatous skin lesions and arthritis in children are not a common association. We present the case of a 3 year old girl who presented with xanthomatous lesions in the periungual region of both hands, around the nares and on her forehead, associated with significant arthritis that was clinically compatible with multicentric reticulohistiocytosis. However, pathology of the xanthomatous lesions was more suggestive of papular xanthoma, a disease that is not associated with arthritis. Based on her presentation and the negative lipid workup, she was treated for presumed multicentric reticulohistiocytosis. Multiple treatment strategies were utilized, with improvement on a combination of infliximab, methotrexate, and prednisone. We review the different diagnoses that should be considered in children with xanthomas and arthritis as well as the different pharmacologic therapies used in children with multicentric reticulohistiocytosis.

Original languageEnglish (US)
Article number1546
Number of pages1
JournalPediatric Rheumatology
Volume7
DOIs
StatePublished - Oct 8 2009

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Xanthomatosis
Arthritis
Forehead
Prednisone
Methotrexate
Hand
Pathology
Lipids
Skin
Therapeutics

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Rheumatology
  • Immunology and Allergy

Cite this

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title = "Papular xanthomas and erosive arthritis in a 3 year old girl, is this a new MRH variant?",
abstract = "Xanthomatous skin lesions and arthritis in children are not a common association. We present the case of a 3 year old girl who presented with xanthomatous lesions in the periungual region of both hands, around the nares and on her forehead, associated with significant arthritis that was clinically compatible with multicentric reticulohistiocytosis. However, pathology of the xanthomatous lesions was more suggestive of papular xanthoma, a disease that is not associated with arthritis. Based on her presentation and the negative lipid workup, she was treated for presumed multicentric reticulohistiocytosis. Multiple treatment strategies were utilized, with improvement on a combination of infliximab, methotrexate, and prednisone. We review the different diagnoses that should be considered in children with xanthomas and arthritis as well as the different pharmacologic therapies used in children with multicentric reticulohistiocytosis.",
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Papular xanthomas and erosive arthritis in a 3 year old girl, is this a new MRH variant? / Matiz, Catalina; Ferguson, Polly J.; Zaenglein, Andrea; Groh, Brandt; Bingham, Catherine.

In: Pediatric Rheumatology, Vol. 7, 1546, 08.10.2009.

Research output: Contribution to journalArticle

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AU - Matiz, Catalina

AU - Ferguson, Polly J.

AU - Zaenglein, Andrea

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AU - Bingham, Catherine

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