Parabrachial and hypothalamic interaction in sodium appetite

S. Dayawansa, S. Peckins, S. Ruch, Ralph Norgren

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Rats with bilateral lesions of the lateral hypothalamus (LH) fail to exhibit sodium appetite. Lesions of the parabrachial nuclei (PBN) also block salt appetite. The PBN projection to the LH is largely ipsilateral. If these deficits are functionally dependent, damaging the PBN on one side and the LH on the other should also block Na appetite. First, bilateral ibotenic acid lesions of the LH were needed because the electrolytic damage used previously destroyed both cells and axons. The ibotenic LH lesions produced substantial weight loss and eliminated Na appetite. Controls with ipsilateral PBN and LH lesions gained weight and displayed robust sodium appetite. The rats with asymmetric PBN-LH lesions also gained weight, but after sodium depletion consistently failed to increase intake of 0.5 M NaCl. These results dissociate loss of sodium appetite from the classic weight loss after LH damage and prove that Na appetite requires communication between neurons in the LH and the PBN.

Original languageEnglish (US)
Pages (from-to)1091-1099
Number of pages9
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume300
Issue number5
DOIs
StatePublished - May 1 2011

Fingerprint

Lateral Hypothalamic Area
Appetite
Sodium
Weight Loss
Ibotenic Acid
Weights and Measures
Axons
Parabrachial Nucleus
Salts
Communication
Neurons

All Science Journal Classification (ASJC) codes

  • Physiology
  • Physiology (medical)

Cite this

Dayawansa, S. ; Peckins, S. ; Ruch, S. ; Norgren, Ralph. / Parabrachial and hypothalamic interaction in sodium appetite. In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 2011 ; Vol. 300, No. 5. pp. 1091-1099.
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Parabrachial and hypothalamic interaction in sodium appetite. / Dayawansa, S.; Peckins, S.; Ruch, S.; Norgren, Ralph.

In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 300, No. 5, 01.05.2011, p. 1091-1099.

Research output: Contribution to journalArticle

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