Parabrachial Gustatory Lesions Impair Taste Aversion Learning in Rats

Alan C. Spector, Ralph Norgren, Harvey J. Grill

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Abstract

Lesions in the gustatory zone of the parabrachial nuclei (PBN) severely impair acquisition of a conditioned taste aversion (CTA) in rats. To test whether this deficit has a memorial basis, intact rats (n = 15) and rats with PBN lesions (PBNX; n = 10) received seven intraoral taste stimulus infusions (30 s, 0.5 ml) distributed over a 30.5-min period after either LiCl or NaCl injection. This task measures the rapid formation of a CTA and has minimum demands on memory. LiCl-injected intact rats progressively changed their oromotor response profile from one of ingestion to one of aversion. NaCl-injected intact rats did not change their ingestive pattern of responding. In contrast, there was no difference between LiCl- and NaCl-injected PBNX rats. These same PBNX rats failed to avoid licking the taste stimulus when tested in a different paradigm. A simple impairment in a memorial process is not likely the basis for the CTA deficit.

Original languageEnglish (US)
Pages (from-to)147-161
Number of pages15
JournalBehavioral Neuroscience
Volume106
Issue number1
DOIs
StatePublished - Feb 1992

All Science Journal Classification (ASJC) codes

  • Behavioral Neuroscience

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