Parabrachial nucleus lesions and conditioned taste aversion: Evidence supporting an associative deficit

Research output: Contribution to journalArticle

112 Citations (Scopus)

Abstract

Three experiments examined the conditioned taste aversion (CTA) deficit that occurs following electrolytic lesions of the parabrachial nucleus (PBN). In Experiment 1, lesioned rats failed to avoid either a gustatory or an olfactory stimulus that had been paired with lithium chloride-induced toxicosis. In Experiment 2, however, all rats learned a conditioned flavor preference. Finally, in Experiment 3, all controls and 7 of the 12 lesioned rats learned a conditioned place aversion. Together, these results demonstrate that the disruption of CTA in lesioned rats cannot be ascribed to an inability to process either gustatory or visceral afferent information per se. Rather, the data suggest that PBN-lesioned rats are unable to form a specific association between gustatory and visceral cues.

Original languageEnglish (US)
Pages (from-to)1005-1017
Number of pages13
JournalBehavioral Neuroscience
Volume107
Issue number6
DOIs
StatePublished - Dec 1 1993

Fingerprint

Visceral Afferents
Lithium Chloride
Cues
Parabrachial Nucleus

All Science Journal Classification (ASJC) codes

  • Behavioral Neuroscience

Cite this

@article{492c0b225f684c86967e43434fdbbcc2,
title = "Parabrachial nucleus lesions and conditioned taste aversion: Evidence supporting an associative deficit",
abstract = "Three experiments examined the conditioned taste aversion (CTA) deficit that occurs following electrolytic lesions of the parabrachial nucleus (PBN). In Experiment 1, lesioned rats failed to avoid either a gustatory or an olfactory stimulus that had been paired with lithium chloride-induced toxicosis. In Experiment 2, however, all rats learned a conditioned flavor preference. Finally, in Experiment 3, all controls and 7 of the 12 lesioned rats learned a conditioned place aversion. Together, these results demonstrate that the disruption of CTA in lesioned rats cannot be ascribed to an inability to process either gustatory or visceral afferent information per se. Rather, the data suggest that PBN-lesioned rats are unable to form a specific association between gustatory and visceral cues.",
author = "S. Reilly and Grigson-Kennedy, {Patricia {"}Sue{"}} and Ralph Norgren",
year = "1993",
month = "12",
day = "1",
doi = "10.1037/0735-7044.107.6.1005",
language = "English (US)",
volume = "107",
pages = "1005--1017",
journal = "Behavioral Neuroscience",
issn = "0735-7044",
publisher = "American Psychological Association Inc.",
number = "6",

}

TY - JOUR

T1 - Parabrachial nucleus lesions and conditioned taste aversion

T2 - Evidence supporting an associative deficit

AU - Reilly, S.

AU - Grigson-Kennedy, Patricia "Sue"

AU - Norgren, Ralph

PY - 1993/12/1

Y1 - 1993/12/1

N2 - Three experiments examined the conditioned taste aversion (CTA) deficit that occurs following electrolytic lesions of the parabrachial nucleus (PBN). In Experiment 1, lesioned rats failed to avoid either a gustatory or an olfactory stimulus that had been paired with lithium chloride-induced toxicosis. In Experiment 2, however, all rats learned a conditioned flavor preference. Finally, in Experiment 3, all controls and 7 of the 12 lesioned rats learned a conditioned place aversion. Together, these results demonstrate that the disruption of CTA in lesioned rats cannot be ascribed to an inability to process either gustatory or visceral afferent information per se. Rather, the data suggest that PBN-lesioned rats are unable to form a specific association between gustatory and visceral cues.

AB - Three experiments examined the conditioned taste aversion (CTA) deficit that occurs following electrolytic lesions of the parabrachial nucleus (PBN). In Experiment 1, lesioned rats failed to avoid either a gustatory or an olfactory stimulus that had been paired with lithium chloride-induced toxicosis. In Experiment 2, however, all rats learned a conditioned flavor preference. Finally, in Experiment 3, all controls and 7 of the 12 lesioned rats learned a conditioned place aversion. Together, these results demonstrate that the disruption of CTA in lesioned rats cannot be ascribed to an inability to process either gustatory or visceral afferent information per se. Rather, the data suggest that PBN-lesioned rats are unable to form a specific association between gustatory and visceral cues.

UR - http://www.scopus.com/inward/record.url?scp=0027738962&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027738962&partnerID=8YFLogxK

U2 - 10.1037/0735-7044.107.6.1005

DO - 10.1037/0735-7044.107.6.1005

M3 - Article

C2 - 8136054

AN - SCOPUS:0027738962

VL - 107

SP - 1005

EP - 1017

JO - Behavioral Neuroscience

JF - Behavioral Neuroscience

SN - 0735-7044

IS - 6

ER -