Parabrachial nucleus lesions block taste and attenuate flavor preference and aversion conditioning in rats

Anthony Sclafani, Anthony V. Azzara, Khalid Touzani, Patricia Sue Grigson, Ralph Norgren

Research output: Contribution to journalArticlepeer-review

48 Scopus citations

Abstract

Rats with ibotenic acid lesions of the parabrachial nucleus (PBN) failed to learn a taste aversion induced by lithium chloride (LiCI) toxicosis. The same rats also did not learn to prefer a taste that was paired with intragastric (IG) carbohydrate infusions during 22 hr/day trials. The PBN-lesioned rats did learn to prefer a flavor (odor + taste) paired with the IG carbohydrate infusions over a different flavor paired with IG water. The PBN-lesioned rats also learned to avoid a flavor paired with IG LiCI infusions during 22 hr/day trials. The flavor preference and aversion, however, were less pronounced than those displayed by control rats. These data indicate that the PBN is essential for forming orosensory-viscerosensory associations when taste is the primary cue but is less critical when more complex flavor cues are available.

Original languageEnglish (US)
Pages (from-to)920-933
Number of pages14
JournalBehavioral Neuroscience
Volume115
Issue number4
DOIs
StatePublished - 2001

All Science Journal Classification (ASJC) codes

  • Behavioral Neuroscience

Fingerprint Dive into the research topics of 'Parabrachial nucleus lesions block taste and attenuate flavor preference and aversion conditioning in rats'. Together they form a unique fingerprint.

Cite this