Parallel multifactor dimensionality reduction: A tool for the large-scale analysis of gene-gene interactions

William S. Bush, Scott M. Dudek, Marylyn D. Ritchie

Research output: Contribution to journalArticlepeer-review

58 Scopus citations

Abstract

Summary: Parallel multifactor dimensionality reduction is a tool for large-scale analysis of gene-gene and gene-environment interactions. The MDR algorithm was redesigned to allow an unlimited number of study subjects, total variables and variable states, and to remove restrictions on the order of interactions being analyzed. In addition, the algorithm is markedly more efficient, with ∼150-fold decrease in runtime for equivalent analyses. To facilitate the processing of large datasets, the algorithm was made parallel.

Original languageEnglish (US)
Pages (from-to)2173-2174
Number of pages2
JournalBioinformatics
Volume22
Issue number17
DOIs
StatePublished - Sep 1 2006

All Science Journal Classification (ASJC) codes

  • Statistics and Probability
  • Biochemistry
  • Molecular Biology
  • Computer Science Applications
  • Computational Theory and Mathematics
  • Computational Mathematics

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