Paramyxovirus assembly and budding: Building particles that transmit infections

Megan S. Harrison, Takemasa Sakaguchi, Anthony P. Schmitt

Research output: Contribution to journalReview article

114 Scopus citations

Abstract

The paramyxoviruses define a diverse group of enveloped RNA viruses that includes a number of important human and animal pathogens. Examples include human respiratory syncytial virus and the human parainfluenza viruses, which cause respiratory illnesses in young children and the elderly; measles and mumps viruses, which have caused recent resurgences of disease in developed countries; the zoonotic Hendra and Nipah viruses, which have caused several outbreaks of fatal disease in Australia and Asia; and Newcastle disease virus, which infects chickens and other avian species. Like other enveloped viruses, paramyxoviruses form particles that assemble and bud from cellular membranes, allowing the transmission of infections to new cells and hosts. Here, we review recent advances that have improved our understanding of events involved in paramyxovirus particle formation. Contributions of viral matrix proteins, glycoproteins, nucleocapsid proteins, and accessory proteins to particle formation are discussed, as well as the importance of host factor recruitment for efficient virus budding. Trafficking of viral structural components within infected cells is described, together with mechanisms that allow for the selection of specific sites on cellular membranes for the coalescence of viral proteins in preparation of bud formation and virion release.

Original languageEnglish (US)
Pages (from-to)1416-1429
Number of pages14
JournalInternational Journal of Biochemistry and Cell Biology
Volume42
Issue number9
DOIs
StatePublished - Sep 2010

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Cell Biology

Fingerprint Dive into the research topics of 'Paramyxovirus assembly and budding: Building particles that transmit infections'. Together they form a unique fingerprint.

  • Cite this