Paramyxovirus assembly and budding: Building particles that transmit infections

Megan S. Harrison, Takemasa Sakaguchi, Anthony Paul Schmitt

Research output: Contribution to journalReview article

107 Citations (Scopus)

Abstract

The paramyxoviruses define a diverse group of enveloped RNA viruses that includes a number of important human and animal pathogens. Examples include human respiratory syncytial virus and the human parainfluenza viruses, which cause respiratory illnesses in young children and the elderly; measles and mumps viruses, which have caused recent resurgences of disease in developed countries; the zoonotic Hendra and Nipah viruses, which have caused several outbreaks of fatal disease in Australia and Asia; and Newcastle disease virus, which infects chickens and other avian species. Like other enveloped viruses, paramyxoviruses form particles that assemble and bud from cellular membranes, allowing the transmission of infections to new cells and hosts. Here, we review recent advances that have improved our understanding of events involved in paramyxovirus particle formation. Contributions of viral matrix proteins, glycoproteins, nucleocapsid proteins, and accessory proteins to particle formation are discussed, as well as the importance of host factor recruitment for efficient virus budding. Trafficking of viral structural components within infected cells is described, together with mechanisms that allow for the selection of specific sites on cellular membranes for the coalescence of viral proteins in preparation of bud formation and virion release.

Original languageEnglish (US)
Pages (from-to)1416-1429
Number of pages14
JournalInternational Journal of Biochemistry and Cell Biology
Volume42
Issue number9
DOIs
StatePublished - Sep 1 2010

Fingerprint

Viral Matrix Proteins
Viruses
Hendra Virus
Nipah Virus
Human respiratory syncytial virus
Mumps virus
Virus Release
Nucleocapsid Proteins
Paramyxoviridae Infections
Newcastle disease virus
Viral Structures
Measles virus
Infectious Disease Transmission
RNA Viruses
Zoonoses
Infection
Developed Countries
Virion
Disease Outbreaks
Chickens

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Cell Biology
  • Medicine(all)

Cite this

@article{2c60b02e649b46efbcf23097a2b8c233,
title = "Paramyxovirus assembly and budding: Building particles that transmit infections",
abstract = "The paramyxoviruses define a diverse group of enveloped RNA viruses that includes a number of important human and animal pathogens. Examples include human respiratory syncytial virus and the human parainfluenza viruses, which cause respiratory illnesses in young children and the elderly; measles and mumps viruses, which have caused recent resurgences of disease in developed countries; the zoonotic Hendra and Nipah viruses, which have caused several outbreaks of fatal disease in Australia and Asia; and Newcastle disease virus, which infects chickens and other avian species. Like other enveloped viruses, paramyxoviruses form particles that assemble and bud from cellular membranes, allowing the transmission of infections to new cells and hosts. Here, we review recent advances that have improved our understanding of events involved in paramyxovirus particle formation. Contributions of viral matrix proteins, glycoproteins, nucleocapsid proteins, and accessory proteins to particle formation are discussed, as well as the importance of host factor recruitment for efficient virus budding. Trafficking of viral structural components within infected cells is described, together with mechanisms that allow for the selection of specific sites on cellular membranes for the coalescence of viral proteins in preparation of bud formation and virion release.",
author = "Harrison, {Megan S.} and Takemasa Sakaguchi and Schmitt, {Anthony Paul}",
year = "2010",
month = "9",
day = "1",
doi = "10.1016/j.biocel.2010.04.005",
language = "English (US)",
volume = "42",
pages = "1416--1429",
journal = "International Journal of Biochemistry and Cell Biology",
issn = "1357-2725",
publisher = "Elsevier Limited",
number = "9",

}

Paramyxovirus assembly and budding : Building particles that transmit infections. / Harrison, Megan S.; Sakaguchi, Takemasa; Schmitt, Anthony Paul.

In: International Journal of Biochemistry and Cell Biology, Vol. 42, No. 9, 01.09.2010, p. 1416-1429.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Paramyxovirus assembly and budding

T2 - Building particles that transmit infections

AU - Harrison, Megan S.

AU - Sakaguchi, Takemasa

AU - Schmitt, Anthony Paul

PY - 2010/9/1

Y1 - 2010/9/1

N2 - The paramyxoviruses define a diverse group of enveloped RNA viruses that includes a number of important human and animal pathogens. Examples include human respiratory syncytial virus and the human parainfluenza viruses, which cause respiratory illnesses in young children and the elderly; measles and mumps viruses, which have caused recent resurgences of disease in developed countries; the zoonotic Hendra and Nipah viruses, which have caused several outbreaks of fatal disease in Australia and Asia; and Newcastle disease virus, which infects chickens and other avian species. Like other enveloped viruses, paramyxoviruses form particles that assemble and bud from cellular membranes, allowing the transmission of infections to new cells and hosts. Here, we review recent advances that have improved our understanding of events involved in paramyxovirus particle formation. Contributions of viral matrix proteins, glycoproteins, nucleocapsid proteins, and accessory proteins to particle formation are discussed, as well as the importance of host factor recruitment for efficient virus budding. Trafficking of viral structural components within infected cells is described, together with mechanisms that allow for the selection of specific sites on cellular membranes for the coalescence of viral proteins in preparation of bud formation and virion release.

AB - The paramyxoviruses define a diverse group of enveloped RNA viruses that includes a number of important human and animal pathogens. Examples include human respiratory syncytial virus and the human parainfluenza viruses, which cause respiratory illnesses in young children and the elderly; measles and mumps viruses, which have caused recent resurgences of disease in developed countries; the zoonotic Hendra and Nipah viruses, which have caused several outbreaks of fatal disease in Australia and Asia; and Newcastle disease virus, which infects chickens and other avian species. Like other enveloped viruses, paramyxoviruses form particles that assemble and bud from cellular membranes, allowing the transmission of infections to new cells and hosts. Here, we review recent advances that have improved our understanding of events involved in paramyxovirus particle formation. Contributions of viral matrix proteins, glycoproteins, nucleocapsid proteins, and accessory proteins to particle formation are discussed, as well as the importance of host factor recruitment for efficient virus budding. Trafficking of viral structural components within infected cells is described, together with mechanisms that allow for the selection of specific sites on cellular membranes for the coalescence of viral proteins in preparation of bud formation and virion release.

UR - http://www.scopus.com/inward/record.url?scp=77955097134&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77955097134&partnerID=8YFLogxK

U2 - 10.1016/j.biocel.2010.04.005

DO - 10.1016/j.biocel.2010.04.005

M3 - Review article

C2 - 20398786

AN - SCOPUS:77955097134

VL - 42

SP - 1416

EP - 1429

JO - International Journal of Biochemistry and Cell Biology

JF - International Journal of Biochemistry and Cell Biology

SN - 1357-2725

IS - 9

ER -