Paraproteinemia and neuropathy

Research output: Contribution to journalReview article

23 Scopus citations

Abstract

Paraprotein-associated neuropathies are a diverse group of disorders. The pathogenesis of many of them is poorly understood. Treatments have usually consisted of plasma exchange, corticosteroids, intravenous immunoglobulin, and other immunosuppressive therapies. Response to treatment has varied from good to very poor. Most recent work in this field has had two goals: achieving a better understanding of pathogenesis and developing better treatments. Such diverse entities as hepatitis C virus, vascular endothelial growth factor, and cytokines now appear to play a role in pathogenesis. More aggressive therapies such a bone marrow transplantation, interferon-α, and Rituximab have shown some promise.

Original languageEnglish (US)
Pages (from-to)589-595
Number of pages7
JournalCurrent Opinion in Neurology
Volume12
Issue number5
DOIs
StatePublished - Dec 1 1999

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

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