Parasitic castration by the digenian trematode Allopodocotyle sp. alters gene expression in the brain of the host mollusc Haliotis asinina

Tamika Rice, Elizabeth McGraw, Elizabeth K. O'Brien, Antonio Reverter, Daniel J. Jackson, Bernard M. Degnan

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Infection of molluscs by digenean trematode parasites typically results in the repression of reproduction - the so-called parasitic castration. This is known to occur by altering the expression of a range of host neuropeptide genes. Here we analyse the expression levels of 10 members of POU, Pax, Sox and Hox transcription factor gene families, along with genes encoding FMRFamide, prohormone convertase and β-tubulin, in the brain ganglia of actively reproducing (summer), non-reproducing (winter) and infected Haliotis asinina (a vetigastropod mollusc). A number of the regulatory genes are differentially expressed in parasitised H. asinina, but in only a few cases do expression patterns in infected animals match those occurring in animals where reproduction is normally repressed.

Original languageEnglish (US)
Pages (from-to)3769-3774
Number of pages6
JournalFEBS Letters
Volume580
Issue number15
DOIs
StatePublished - Jun 26 2006

Fingerprint

Molluscs
Mollusca
Castration
Gene expression
Brain
Genes
Gene Expression
Reproduction
Animals
FMRFamide
Proprotein Convertases
Gene encoding
Regulator Genes
Tubulin
Neuropeptides
Ganglia
Parasites
Transcription Factors
Infection

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

Cite this

Rice, Tamika ; McGraw, Elizabeth ; O'Brien, Elizabeth K. ; Reverter, Antonio ; Jackson, Daniel J. ; Degnan, Bernard M. / Parasitic castration by the digenian trematode Allopodocotyle sp. alters gene expression in the brain of the host mollusc Haliotis asinina. In: FEBS Letters. 2006 ; Vol. 580, No. 15. pp. 3769-3774.
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Parasitic castration by the digenian trematode Allopodocotyle sp. alters gene expression in the brain of the host mollusc Haliotis asinina. / Rice, Tamika; McGraw, Elizabeth; O'Brien, Elizabeth K.; Reverter, Antonio; Jackson, Daniel J.; Degnan, Bernard M.

In: FEBS Letters, Vol. 580, No. 15, 26.06.2006, p. 3769-3774.

Research output: Contribution to journalArticle

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