Parathyroid hormone-related protein: a developmental regulatory molecule necessary for mammary gland development.

Maureen E. Dunbar, J. J. Wysolmerski

Research output: Contribution to journalReview article

57 Citations (Scopus)

Abstract

Parathyroid hormone-related protein (PTHrP) was originally identified as the tumor factor responsible for a clinical syndrome known as humoral hypercalcemia of malignancy. It is now appreciated that PTHrP3 is a developmental regulatory molecule expressed during the formation of a wide variety of organs. Recently, our laboratory has demonstrated that PTHrP is necessary for mammary gland development. Our studies have suggested that this molecule participates in the regulation of epithelial-mesenchymal interactions during embryonic mammary development and perhaps also during adolescent ductal morphogenesis. In addition, it has been suggested that PTHrP plays a critical role in the establishment of bone metastases in breast cancer. In this article, we will discuss the current knowledge of the mechanisms underlying PTHrPs actions during normal mammary development and in breast cancer.

Original languageEnglish (US)
Pages (from-to)21-34
Number of pages14
JournalJournal of Mammary Gland Biology and Neoplasia
Volume4
Issue number1
DOIs
StatePublished - Jan 1 1999

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Parathyroid Hormone-Related Protein
Human Mammary Glands
Breast
Breast Neoplasms
Morphogenesis
Embryonic Development
Neoplasm Metastasis
Bone and Bones
Neoplasms

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

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abstract = "Parathyroid hormone-related protein (PTHrP) was originally identified as the tumor factor responsible for a clinical syndrome known as humoral hypercalcemia of malignancy. It is now appreciated that PTHrP3 is a developmental regulatory molecule expressed during the formation of a wide variety of organs. Recently, our laboratory has demonstrated that PTHrP is necessary for mammary gland development. Our studies have suggested that this molecule participates in the regulation of epithelial-mesenchymal interactions during embryonic mammary development and perhaps also during adolescent ductal morphogenesis. In addition, it has been suggested that PTHrP plays a critical role in the establishment of bone metastases in breast cancer. In this article, we will discuss the current knowledge of the mechanisms underlying PTHrPs actions during normal mammary development and in breast cancer.",
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Parathyroid hormone-related protein : a developmental regulatory molecule necessary for mammary gland development. / Dunbar, Maureen E.; Wysolmerski, J. J.

In: Journal of Mammary Gland Biology and Neoplasia, Vol. 4, No. 1, 01.01.1999, p. 21-34.

Research output: Contribution to journalReview article

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