Parenting and adolescent antisocial behavior and depression

Evidence of genotype x parenting environment interaction

Mark Ethan Feinberg, Tanya M.M. Button, Jenae Marie Neiderhiser, David Reiss, E. Mavis Hetherington

Research output: Contribution to journalArticle

105 Citations (Scopus)

Abstract

Background: Little is known about the interplay of genotypes and malleable risk factors in influencing adolescent psychiatric symptoms and disorders. Information on these processes is crucial in designing programs for the prevention of psychiatric disorders. Objective: To assess whether latent genetic factors and measured parent-child relationships interact (GXE) in predicting adolescent antisocial behavior and depression. Design: We characterized risk of antisocial behavior and depression in adolescents by means of a genetically informed design. We used in-home questionnaire and observational measures of adolescent outcomes and environmental moderators (parenting), and a latent variable behavior genetic analytic model. Setting: A nationally distributed sample recruited from random-digit dialing and national market panels. Participants: A total of 720 families with at least 2 children, 9 through 18 years old, stratified by genetic relatedness (monozygotic and dizygotic twins, full biological siblings in nondivorced and stepfamilies, and halfsiblings and biologically unrelated siblings in stepfamilies). Main Outcome Measures: Antisocial behavior and depressive symptoms. Results: There was an interaction of genotype and both parental negativity and low warmth predicting overall antisocial behavior, as well as aggressive and nonaggressive forms of antisocial behavior, but not depression. Genetic influence was greater for adolescent antisocial behavior when parenting was more negative or less warm. Genotype-environment correlation was partialled out in the analysis and thus did not account for the results. Conclusion: This study demonstrates, on the basis of careful measurement and appropriate analytic methods, that a continuous measure of parenting in the normative range moderates the influence of genotype on antisocial behavior.

Original languageEnglish (US)
Pages (from-to)457-465
Number of pages9
JournalArchives of General Psychiatry
Volume64
Issue number4
DOIs
StatePublished - Apr 1 2007

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Adolescent Behavior
Parenting
Genotype
Depression
Siblings
Outcome Assessment (Health Care)
Adolescent Psychiatry
Parent-Child Relations
Dizygotic Twins
Monozygotic Twins
Genetic Models
Risk-Taking
Psychiatry
Interaction

All Science Journal Classification (ASJC) codes

  • Arts and Humanities (miscellaneous)
  • Psychiatry and Mental health

Cite this

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abstract = "Background: Little is known about the interplay of genotypes and malleable risk factors in influencing adolescent psychiatric symptoms and disorders. Information on these processes is crucial in designing programs for the prevention of psychiatric disorders. Objective: To assess whether latent genetic factors and measured parent-child relationships interact (GXE) in predicting adolescent antisocial behavior and depression. Design: We characterized risk of antisocial behavior and depression in adolescents by means of a genetically informed design. We used in-home questionnaire and observational measures of adolescent outcomes and environmental moderators (parenting), and a latent variable behavior genetic analytic model. Setting: A nationally distributed sample recruited from random-digit dialing and national market panels. Participants: A total of 720 families with at least 2 children, 9 through 18 years old, stratified by genetic relatedness (monozygotic and dizygotic twins, full biological siblings in nondivorced and stepfamilies, and halfsiblings and biologically unrelated siblings in stepfamilies). Main Outcome Measures: Antisocial behavior and depressive symptoms. Results: There was an interaction of genotype and both parental negativity and low warmth predicting overall antisocial behavior, as well as aggressive and nonaggressive forms of antisocial behavior, but not depression. Genetic influence was greater for adolescent antisocial behavior when parenting was more negative or less warm. Genotype-environment correlation was partialled out in the analysis and thus did not account for the results. Conclusion: This study demonstrates, on the basis of careful measurement and appropriate analytic methods, that a continuous measure of parenting in the normative range moderates the influence of genotype on antisocial behavior.",
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Parenting and adolescent antisocial behavior and depression : Evidence of genotype x parenting environment interaction. / Feinberg, Mark Ethan; Button, Tanya M.M.; Neiderhiser, Jenae Marie; Reiss, David; Hetherington, E. Mavis.

In: Archives of General Psychiatry, Vol. 64, No. 4, 01.04.2007, p. 457-465.

Research output: Contribution to journalArticle

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