Parotid gland injections of botulinum toxin A are effective in treating sialorrhea in amyotrophic lateral sclerosis

Kevin R. Scott, Milind J. Kothari, Y. Swami Venkatesh, Tamara Murphy, Zachary Simmons

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Objective: The objective of this study was to determine the safety and efficacy of botulinum toxin A in ameliorating refractory sialorrhea and improving quality of life in patients with amyotrophic lateral sclerosis. Materials and Methods: Six patients with bulbar ALS received bilateral parotid gland injections of botulinum toxin A. Results: No adverse effects occurred. Tissue use decreased in 5 of 7 patients at a dose of 10 units and in 3 of 4 patients at a dose of 20 units. Self-reported quality of life did not change in most. Conclusions: Parotid gland injections of botulinum toxin appear safe and may be helpful in some patients with ALS for the treatment of sialorrhea.

Original languageEnglish (US)
Pages (from-to)62-65
Number of pages4
JournalJournal of clinical neuromuscular disease
Volume7
Issue number2
DOIs
StatePublished - Dec 1 2005

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

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