Objective: The objective of this study was to determine the safety and efficacy of botulinum toxin A in ameliorating refractory sialorrhea and improving quality of life in patients with amyotrophic lateral sclerosis. Materials and Methods: Six patients with bulbar ALS received bilateral parotid gland injections of botulinum toxin A. Results: No adverse effects occurred. Tissue use decreased in 5 of 7 patients at a dose of 10 units and in 3 of 4 patients at a dose of 20 units. Self-reported quality of life did not change in most. Conclusions: Parotid gland injections of botulinum toxin appear safe and may be helpful in some patients with ALS for the treatment of sialorrhea.
|Original language||English (US)|
|Number of pages||4|
|Journal||Journal of clinical neuromuscular disease|
|State||Published - Dec 1 2005|
All Science Journal Classification (ASJC) codes
- Clinical Neurology