Parotid gland injections of botulinum toxin A are effective in treating sialorrhea in amyotrophic lateral sclerosis

Kevin R. Scott, Milind J. Kothari, Y. Swami Venkatesh, Tamara Murphy, Zachary Simmons

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Objective: The objective of this study was to determine the safety and efficacy of botulinum toxin A in ameliorating refractory sialorrhea and improving quality of life in patients with amyotrophic lateral sclerosis. Materials and Methods: Six patients with bulbar ALS received bilateral parotid gland injections of botulinum toxin A. Results: No adverse effects occurred. Tissue use decreased in 5 of 7 patients at a dose of 10 units and in 3 of 4 patients at a dose of 20 units. Self-reported quality of life did not change in most. Conclusions: Parotid gland injections of botulinum toxin appear safe and may be helpful in some patients with ALS for the treatment of sialorrhea.

Original languageEnglish (US)
Pages (from-to)62-65
Number of pages4
JournalJournal of Clinical Neuromuscular Disease
Volume7
Issue number2
DOIs
StatePublished - Dec 1 2005

Fingerprint

Sialorrhea
Type A Botulinum Toxins
Parotid Gland
Amyotrophic Lateral Sclerosis
Injections
Quality of Life
Botulinum Toxins
Safety

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cite this

Scott, Kevin R. ; Kothari, Milind J. ; Venkatesh, Y. Swami ; Murphy, Tamara ; Simmons, Zachary. / Parotid gland injections of botulinum toxin A are effective in treating sialorrhea in amyotrophic lateral sclerosis. In: Journal of Clinical Neuromuscular Disease. 2005 ; Vol. 7, No. 2. pp. 62-65.
@article{d189f0b9356b4773bc65f53a1c26a105,
title = "Parotid gland injections of botulinum toxin A are effective in treating sialorrhea in amyotrophic lateral sclerosis",
abstract = "Objective: The objective of this study was to determine the safety and efficacy of botulinum toxin A in ameliorating refractory sialorrhea and improving quality of life in patients with amyotrophic lateral sclerosis. Materials and Methods: Six patients with bulbar ALS received bilateral parotid gland injections of botulinum toxin A. Results: No adverse effects occurred. Tissue use decreased in 5 of 7 patients at a dose of 10 units and in 3 of 4 patients at a dose of 20 units. Self-reported quality of life did not change in most. Conclusions: Parotid gland injections of botulinum toxin appear safe and may be helpful in some patients with ALS for the treatment of sialorrhea.",
author = "Scott, {Kevin R.} and Kothari, {Milind J.} and Venkatesh, {Y. Swami} and Tamara Murphy and Zachary Simmons",
year = "2005",
month = "12",
day = "1",
doi = "10.1097/01.cnd.0000188865.88167.62",
language = "English (US)",
volume = "7",
pages = "62--65",
journal = "Journal of Clinical Neuromuscular Disease",
issn = "1522-0443",
publisher = "Lippincott Williams and Wilkins",
number = "2",

}

Parotid gland injections of botulinum toxin A are effective in treating sialorrhea in amyotrophic lateral sclerosis. / Scott, Kevin R.; Kothari, Milind J.; Venkatesh, Y. Swami; Murphy, Tamara; Simmons, Zachary.

In: Journal of Clinical Neuromuscular Disease, Vol. 7, No. 2, 01.12.2005, p. 62-65.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Parotid gland injections of botulinum toxin A are effective in treating sialorrhea in amyotrophic lateral sclerosis

AU - Scott, Kevin R.

AU - Kothari, Milind J.

AU - Venkatesh, Y. Swami

AU - Murphy, Tamara

AU - Simmons, Zachary

PY - 2005/12/1

Y1 - 2005/12/1

N2 - Objective: The objective of this study was to determine the safety and efficacy of botulinum toxin A in ameliorating refractory sialorrhea and improving quality of life in patients with amyotrophic lateral sclerosis. Materials and Methods: Six patients with bulbar ALS received bilateral parotid gland injections of botulinum toxin A. Results: No adverse effects occurred. Tissue use decreased in 5 of 7 patients at a dose of 10 units and in 3 of 4 patients at a dose of 20 units. Self-reported quality of life did not change in most. Conclusions: Parotid gland injections of botulinum toxin appear safe and may be helpful in some patients with ALS for the treatment of sialorrhea.

AB - Objective: The objective of this study was to determine the safety and efficacy of botulinum toxin A in ameliorating refractory sialorrhea and improving quality of life in patients with amyotrophic lateral sclerosis. Materials and Methods: Six patients with bulbar ALS received bilateral parotid gland injections of botulinum toxin A. Results: No adverse effects occurred. Tissue use decreased in 5 of 7 patients at a dose of 10 units and in 3 of 4 patients at a dose of 20 units. Self-reported quality of life did not change in most. Conclusions: Parotid gland injections of botulinum toxin appear safe and may be helpful in some patients with ALS for the treatment of sialorrhea.

UR - http://www.scopus.com/inward/record.url?scp=28844487495&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=28844487495&partnerID=8YFLogxK

U2 - 10.1097/01.cnd.0000188865.88167.62

DO - 10.1097/01.cnd.0000188865.88167.62

M3 - Article

C2 - 19078785

AN - SCOPUS:28844487495

VL - 7

SP - 62

EP - 65

JO - Journal of Clinical Neuromuscular Disease

JF - Journal of Clinical Neuromuscular Disease

SN - 1522-0443

IS - 2

ER -