Partial AUC for differentiated gene detection

Zhenqiu Liu, Terry Hyslop

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Citations (Scopus)

Abstract

Partial AUC (pAUC) represents the area with a restricted range of specificity (e.g. low false positive rate). It may identify important regional differentiated genes missed by full-range analysis. Unlike the popular t-test, which is based on the mean difference and the standard deviation between the disease and health groups, pAUC based test statistic relies on the rank of a gene in different samples. It can effectively detect genes that are not significant in a t-test and only differentiated in a subset of the disease groups. Our experiments with real gene expression data show that the proposed pAUC statistic is appealing in terms of both detection power and the biological relevance of the results.

Original languageEnglish (US)
Title of host publication10th IEEE International Conference on Bioinformatics and Bioengineering 2010, BIBE 2010
Pages310-311
Number of pages2
DOIs
StatePublished - Sep 6 2010
Event10th IEEE International Conference on Bioinformatics and Bioengineering, BIBE-2010 - Philadelphia, PA, United States
Duration: May 31 2010Jun 3 2010

Publication series

Name10th IEEE International Conference on Bioinformatics and Bioengineering 2010, BIBE 2010

Other

Other10th IEEE International Conference on Bioinformatics and Bioengineering, BIBE-2010
CountryUnited States
CityPhiladelphia, PA
Period5/31/106/3/10

Fingerprint

Area Under Curve
Genes
Statistics
Gene expression
Health
Gene Expression
Experiments

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering
  • Health Informatics

Cite this

Liu, Z., & Hyslop, T. (2010). Partial AUC for differentiated gene detection. In 10th IEEE International Conference on Bioinformatics and Bioengineering 2010, BIBE 2010 (pp. 310-311). [5521659] (10th IEEE International Conference on Bioinformatics and Bioengineering 2010, BIBE 2010). https://doi.org/10.1109/BIBE.2010.68
Liu, Zhenqiu ; Hyslop, Terry. / Partial AUC for differentiated gene detection. 10th IEEE International Conference on Bioinformatics and Bioengineering 2010, BIBE 2010. 2010. pp. 310-311 (10th IEEE International Conference on Bioinformatics and Bioengineering 2010, BIBE 2010).
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Liu, Z & Hyslop, T 2010, Partial AUC for differentiated gene detection. in 10th IEEE International Conference on Bioinformatics and Bioengineering 2010, BIBE 2010., 5521659, 10th IEEE International Conference on Bioinformatics and Bioengineering 2010, BIBE 2010, pp. 310-311, 10th IEEE International Conference on Bioinformatics and Bioengineering, BIBE-2010, Philadelphia, PA, United States, 5/31/10. https://doi.org/10.1109/BIBE.2010.68

Partial AUC for differentiated gene detection. / Liu, Zhenqiu; Hyslop, Terry.

10th IEEE International Conference on Bioinformatics and Bioengineering 2010, BIBE 2010. 2010. p. 310-311 5521659 (10th IEEE International Conference on Bioinformatics and Bioengineering 2010, BIBE 2010).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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Liu Z, Hyslop T. Partial AUC for differentiated gene detection. In 10th IEEE International Conference on Bioinformatics and Bioengineering 2010, BIBE 2010. 2010. p. 310-311. 5521659. (10th IEEE International Conference on Bioinformatics and Bioengineering 2010, BIBE 2010). https://doi.org/10.1109/BIBE.2010.68