Partial likelihood analysis of within-unit variances in repeated measurement experiments

Vernon Chinchilli, J. D. Esinhart, W. G. Miller

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Abstract

The objectives of some experiments are to compare the variances of two or more treatments, products, or techniques. If the investigator is more concerned about within-unit variances rather than between-unit variances, then a repeated measurement design is needed. We invoke a random effects model with heterogeneous within-unit variances for certain repeated measurements designs. We do not impose any distributional assumptions for the random effects, whereas we assume either a normal or multivariate t distribution for the random errors. We propose a partial likelihood analysis for population-based inference and individual-based inference. We illustrate the methodology with an example from a trial comparing serum cholesterol measurements from a routine laboratory analyzer to those of a standardized method.

Original languageEnglish (US)
Pages (from-to)205-216
Number of pages12
JournalBiometrics
Volume51
Issue number1
DOIs
Publication statusPublished - May 30 1995

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All Science Journal Classification (ASJC) codes

  • Statistics and Probability
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Agricultural and Biological Sciences(all)
  • Applied Mathematics

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