Partitioning of population genetic variance under multiplicative-epistatic gene action

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Determining the way in which different QTLs interact (epistasis) in their effects on the phenotype is crucial to many areas in population genetics and evolutionary biology. For example, in the founder event, a separated population readapts to a new environment through the release of cryptic gene-gene interactions. In hybrid zones, hybrid speciation must be subjected to natural selection for epistasis resulting from genomic recombinations between different species. However, there is a severe shortage of relevant methodologies to estimate epistatic genetic effects and variances. A statistical model has recently been proposed to estimate the number of QTLs, their genetic effects and allelic frequencies in segregating populations. This model is based on multiplicative gene action and derived from a two-level intra- and interspecific mating design. In this paper, we formulate a statistical procedure for partitioning the genetic variance into additive, dominant and various kinds of epistatic components in an intra- or mixed intra- and interspecific hybrid population. The procedure can be used to study the genetic architecture of fragmented populations and hybrid zones, thus allowing for a better recognition of the role of epistasis in evolution and hybrid speciation. A real example for two Populus species, P. tremuloides and P. tremula, is provided to illustrate the procedure. In this example, we found that considerable new genetic variation is formed through genomic recombination between two aspen species.

Original languageEnglish (US)
Pages (from-to)743-749
Number of pages7
JournalTheoretical and Applied Genetics
Volume100
Issue number5
DOIs
StatePublished - Jan 1 2000

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Genetic Epistasis
epistasis
Population Genetics
genetic variance
population genetics
Genetic Recombination
Population
Genes
quantitative trait loci
Populus
Genetic Selection
Statistical Models
genomics
Populus tremula
gene interaction
Populus tremuloides
statistical models
natural selection
gene frequency
Phenotype

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Agronomy and Crop Science
  • Genetics

Cite this

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Partitioning of population genetic variance under multiplicative-epistatic gene action. / Wu, R. L.

In: Theoretical and Applied Genetics, Vol. 100, No. 5, 01.01.2000, p. 743-749.

Research output: Contribution to journalArticle

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