Passive deformations and active motions of leukocytes

Richard Skalak, Cheng Dong, Cheng Zhu

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

The purpose of this paper is to review the development of continuum mechanics models of single leukocytes in both passive deformations and active motions and to indicate some future directions. Models of passive deformations describe the overall rheological behavior of single leukocytes under externally applied forces and predict the average mechanical properties from experimental data. Various “apparent” viscoelastic coefficients are obtained depending on the models assumed and the types of test used. Models of spontaneous motions postulate active driving mechanisms which must be derived internally from the cell itself and probably have different bases for different kind of motions. For pseudopod protrusion on leukocytes, energy transduction from chemical potential to mechanical work associated with actin polymerization at the tip of the projection is assumed to supply the motive power. For pseudopod retraction, active contraction due to actin-myosin interaction is assumed to be the driving force. The feasibility of the hypotheses are tested via numerical examples and comparison of the theoretical results with experimental measurements.

Original languageEnglish (US)
Pages (from-to)295-302
Number of pages8
JournalJournal of Biomechanical Engineering
Volume112
Issue number3
DOIs
StatePublished - Jan 1 1990

Fingerprint

Pseudopodia
Leukocytes
Actins
Electric Power Supplies
Myosins
Mechanics
Polymerization
Continuum mechanics
Chemical potential
Mechanical properties
Direction compound

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering
  • Physiology (medical)

Cite this

Skalak, Richard ; Dong, Cheng ; Zhu, Cheng. / Passive deformations and active motions of leukocytes. In: Journal of Biomechanical Engineering. 1990 ; Vol. 112, No. 3. pp. 295-302.
@article{6bdcc086ff224b848ab5d572ddf43d8c,
title = "Passive deformations and active motions of leukocytes",
abstract = "The purpose of this paper is to review the development of continuum mechanics models of single leukocytes in both passive deformations and active motions and to indicate some future directions. Models of passive deformations describe the overall rheological behavior of single leukocytes under externally applied forces and predict the average mechanical properties from experimental data. Various “apparent” viscoelastic coefficients are obtained depending on the models assumed and the types of test used. Models of spontaneous motions postulate active driving mechanisms which must be derived internally from the cell itself and probably have different bases for different kind of motions. For pseudopod protrusion on leukocytes, energy transduction from chemical potential to mechanical work associated with actin polymerization at the tip of the projection is assumed to supply the motive power. For pseudopod retraction, active contraction due to actin-myosin interaction is assumed to be the driving force. The feasibility of the hypotheses are tested via numerical examples and comparison of the theoretical results with experimental measurements.",
author = "Richard Skalak and Cheng Dong and Cheng Zhu",
year = "1990",
month = "1",
day = "1",
doi = "10.1115/1.2891187",
language = "English (US)",
volume = "112",
pages = "295--302",
journal = "Journal of Biomechanical Engineering",
issn = "0148-0731",
publisher = "American Society of Mechanical Engineers(ASME)",
number = "3",

}

Passive deformations and active motions of leukocytes. / Skalak, Richard; Dong, Cheng; Zhu, Cheng.

In: Journal of Biomechanical Engineering, Vol. 112, No. 3, 01.01.1990, p. 295-302.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Passive deformations and active motions of leukocytes

AU - Skalak, Richard

AU - Dong, Cheng

AU - Zhu, Cheng

PY - 1990/1/1

Y1 - 1990/1/1

N2 - The purpose of this paper is to review the development of continuum mechanics models of single leukocytes in both passive deformations and active motions and to indicate some future directions. Models of passive deformations describe the overall rheological behavior of single leukocytes under externally applied forces and predict the average mechanical properties from experimental data. Various “apparent” viscoelastic coefficients are obtained depending on the models assumed and the types of test used. Models of spontaneous motions postulate active driving mechanisms which must be derived internally from the cell itself and probably have different bases for different kind of motions. For pseudopod protrusion on leukocytes, energy transduction from chemical potential to mechanical work associated with actin polymerization at the tip of the projection is assumed to supply the motive power. For pseudopod retraction, active contraction due to actin-myosin interaction is assumed to be the driving force. The feasibility of the hypotheses are tested via numerical examples and comparison of the theoretical results with experimental measurements.

AB - The purpose of this paper is to review the development of continuum mechanics models of single leukocytes in both passive deformations and active motions and to indicate some future directions. Models of passive deformations describe the overall rheological behavior of single leukocytes under externally applied forces and predict the average mechanical properties from experimental data. Various “apparent” viscoelastic coefficients are obtained depending on the models assumed and the types of test used. Models of spontaneous motions postulate active driving mechanisms which must be derived internally from the cell itself and probably have different bases for different kind of motions. For pseudopod protrusion on leukocytes, energy transduction from chemical potential to mechanical work associated with actin polymerization at the tip of the projection is assumed to supply the motive power. For pseudopod retraction, active contraction due to actin-myosin interaction is assumed to be the driving force. The feasibility of the hypotheses are tested via numerical examples and comparison of the theoretical results with experimental measurements.

UR - http://www.scopus.com/inward/record.url?scp=0025469243&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025469243&partnerID=8YFLogxK

U2 - 10.1115/1.2891187

DO - 10.1115/1.2891187

M3 - Article

C2 - 2214711

AN - SCOPUS:0025469243

VL - 112

SP - 295

EP - 302

JO - Journal of Biomechanical Engineering

JF - Journal of Biomechanical Engineering

SN - 0148-0731

IS - 3

ER -