Patch testing in children from 2005 to 2012: Results from the North American contact dermatitis group

Kathryn A. Zug, Anh Khoa Pham, Donald V. Belsito, Joel G. Dekoven, Vincent A. DeLeo, Joseph F. Fowler, Anthony F. Fransway, Howard I. Maibach, James Marks, C. G.Toby Mathias, Melanie D. Pratt, Denis Sasseville, Frances J. Storrs, James S. Taylor, Erin M. Warshaw, Matthew J. Zirwas

Research output: Contribution to journalArticle

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Abstract

Background: Allergic contact dermatitis is common in children. Epicutaneous patch testing is an important tool for identifying responsible allergens. Objective: The objective of this study was to provide the patch test results from children (aged ≤18 years) examined by the North American Contact Dermatitis Group from 2005 to 2012. Methods: This is a retrospective analysis of children patch-tested with the North American Contact Dermatitis Group 65- or 70-allergen series. Frequencies and counts were compared with previously published data (2001-2004) using &Chi2 statistics. Conclusions: A total of 883 children were tested during the study period. A percentage of 62.3% had ≥1 positive patch test and 56.7% had ≥1 relevant positive patch test. Frequencies of positive patch test and relevant positive patch test reaction were highest with nickel sulfate (28.1/25.6), cobalt chloride (12.3/9.1), neomycin sulfate (7.1/6.6), balsam of Peru (5.7/5.5), and lanolin alcohol 50% petrolatum vehicle (5.5/5.1). The >1 positive patch test and Q1 relevant positive patch test in the children did not differ significantly from adults (≥19 years) or from previously tested children (2001-2004). The percentage of clinically relevant positive patch tests for 27 allergens differed significantly between the children and adults. A total of 23.6% of children had a relevant positive reaction to at least 1 supplemental allergen. Differences in positive patch test and relevant positive patch test frequencies between children and adults as well as test periods confirm the importance of reporting periodic updates of patch testing in children to enhance clinicians' vigilance to clinically important allergens.

Original languageEnglish (US)
Pages (from-to)345-355
Number of pages11
JournalDermatitis
Volume25
Issue number6
DOIs
StatePublished - Jan 1 2014

Fingerprint

Patch Tests
Contact Dermatitis
Allergens
Lanolin
Petrolatum
Allergic Contact Dermatitis
Neomycin
Alcohols

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Dermatology

Cite this

Zug, K. A., Pham, A. K., Belsito, D. V., Dekoven, J. G., DeLeo, V. A., Fowler, J. F., ... Zirwas, M. J. (2014). Patch testing in children from 2005 to 2012: Results from the North American contact dermatitis group. Dermatitis, 25(6), 345-355. https://doi.org/10.1097/DER.0000000000000083
Zug, Kathryn A. ; Pham, Anh Khoa ; Belsito, Donald V. ; Dekoven, Joel G. ; DeLeo, Vincent A. ; Fowler, Joseph F. ; Fransway, Anthony F. ; Maibach, Howard I. ; Marks, James ; Mathias, C. G.Toby ; Pratt, Melanie D. ; Sasseville, Denis ; Storrs, Frances J. ; Taylor, James S. ; Warshaw, Erin M. ; Zirwas, Matthew J. / Patch testing in children from 2005 to 2012 : Results from the North American contact dermatitis group. In: Dermatitis. 2014 ; Vol. 25, No. 6. pp. 345-355.
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abstract = "Background: Allergic contact dermatitis is common in children. Epicutaneous patch testing is an important tool for identifying responsible allergens. Objective: The objective of this study was to provide the patch test results from children (aged ≤18 years) examined by the North American Contact Dermatitis Group from 2005 to 2012. Methods: This is a retrospective analysis of children patch-tested with the North American Contact Dermatitis Group 65- or 70-allergen series. Frequencies and counts were compared with previously published data (2001-2004) using &Chi2 statistics. Conclusions: A total of 883 children were tested during the study period. A percentage of 62.3{\%} had ≥1 positive patch test and 56.7{\%} had ≥1 relevant positive patch test. Frequencies of positive patch test and relevant positive patch test reaction were highest with nickel sulfate (28.1/25.6), cobalt chloride (12.3/9.1), neomycin sulfate (7.1/6.6), balsam of Peru (5.7/5.5), and lanolin alcohol 50{\%} petrolatum vehicle (5.5/5.1). The >1 positive patch test and Q1 relevant positive patch test in the children did not differ significantly from adults (≥19 years) or from previously tested children (2001-2004). The percentage of clinically relevant positive patch tests for 27 allergens differed significantly between the children and adults. A total of 23.6{\%} of children had a relevant positive reaction to at least 1 supplemental allergen. Differences in positive patch test and relevant positive patch test frequencies between children and adults as well as test periods confirm the importance of reporting periodic updates of patch testing in children to enhance clinicians' vigilance to clinically important allergens.",
author = "Zug, {Kathryn A.} and Pham, {Anh Khoa} and Belsito, {Donald V.} and Dekoven, {Joel G.} and DeLeo, {Vincent A.} and Fowler, {Joseph F.} and Fransway, {Anthony F.} and Maibach, {Howard I.} and James Marks and Mathias, {C. G.Toby} and Pratt, {Melanie D.} and Denis Sasseville and Storrs, {Frances J.} and Taylor, {James S.} and Warshaw, {Erin M.} and Zirwas, {Matthew J.}",
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Zug, KA, Pham, AK, Belsito, DV, Dekoven, JG, DeLeo, VA, Fowler, JF, Fransway, AF, Maibach, HI, Marks, J, Mathias, CGT, Pratt, MD, Sasseville, D, Storrs, FJ, Taylor, JS, Warshaw, EM & Zirwas, MJ 2014, 'Patch testing in children from 2005 to 2012: Results from the North American contact dermatitis group', Dermatitis, vol. 25, no. 6, pp. 345-355. https://doi.org/10.1097/DER.0000000000000083

Patch testing in children from 2005 to 2012 : Results from the North American contact dermatitis group. / Zug, Kathryn A.; Pham, Anh Khoa; Belsito, Donald V.; Dekoven, Joel G.; DeLeo, Vincent A.; Fowler, Joseph F.; Fransway, Anthony F.; Maibach, Howard I.; Marks, James; Mathias, C. G.Toby; Pratt, Melanie D.; Sasseville, Denis; Storrs, Frances J.; Taylor, James S.; Warshaw, Erin M.; Zirwas, Matthew J.

In: Dermatitis, Vol. 25, No. 6, 01.01.2014, p. 345-355.

Research output: Contribution to journalArticle

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T1 - Patch testing in children from 2005 to 2012

T2 - Results from the North American contact dermatitis group

AU - Zug, Kathryn A.

AU - Pham, Anh Khoa

AU - Belsito, Donald V.

AU - Dekoven, Joel G.

AU - DeLeo, Vincent A.

AU - Fowler, Joseph F.

AU - Fransway, Anthony F.

AU - Maibach, Howard I.

AU - Marks, James

AU - Mathias, C. G.Toby

AU - Pratt, Melanie D.

AU - Sasseville, Denis

AU - Storrs, Frances J.

AU - Taylor, James S.

AU - Warshaw, Erin M.

AU - Zirwas, Matthew J.

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Background: Allergic contact dermatitis is common in children. Epicutaneous patch testing is an important tool for identifying responsible allergens. Objective: The objective of this study was to provide the patch test results from children (aged ≤18 years) examined by the North American Contact Dermatitis Group from 2005 to 2012. Methods: This is a retrospective analysis of children patch-tested with the North American Contact Dermatitis Group 65- or 70-allergen series. Frequencies and counts were compared with previously published data (2001-2004) using &Chi2 statistics. Conclusions: A total of 883 children were tested during the study period. A percentage of 62.3% had ≥1 positive patch test and 56.7% had ≥1 relevant positive patch test. Frequencies of positive patch test and relevant positive patch test reaction were highest with nickel sulfate (28.1/25.6), cobalt chloride (12.3/9.1), neomycin sulfate (7.1/6.6), balsam of Peru (5.7/5.5), and lanolin alcohol 50% petrolatum vehicle (5.5/5.1). The >1 positive patch test and Q1 relevant positive patch test in the children did not differ significantly from adults (≥19 years) or from previously tested children (2001-2004). The percentage of clinically relevant positive patch tests for 27 allergens differed significantly between the children and adults. A total of 23.6% of children had a relevant positive reaction to at least 1 supplemental allergen. Differences in positive patch test and relevant positive patch test frequencies between children and adults as well as test periods confirm the importance of reporting periodic updates of patch testing in children to enhance clinicians' vigilance to clinically important allergens.

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