Pathological changes in exposed neural tissue of fetal delayed splotch (Spd) mice

David G. McLone, Mark Dias, William Goossens, Paul A. Knepper

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

If meningomyelocele is indeed a progressive intrauterine process, then early delivery or possibly intrauterine repair of meningomyelocele becomes an issue. Utilizing the delayed splotch (Spd) mouse, a genetically transmitted neural tube defect model, we looked for evidence of abnormalities of neural tissue exposed to amniotic fluid. Affected embryonic and fetal mice were examined with the light microscope, and also with the transmission and scanning electron microscope. Neuronal development and programmed cell death paralleled normal fetal development. No evidence of inflammation on or within the exposed neural tissue was observed. Because the vascular supply to the alar and basilar plate are different, vascular development was also examined and no difference could be found. In conclusion, we found no evidence of deterioration of the exposed neural tube during the gestational period of a mouse, which suggests that exposure of unneurulated spinal cord to amniotic fluid is not a risk factor to the fetus with a neural tube defect.

Original languageEnglish (US)
Pages (from-to)1-7
Number of pages7
JournalChild's Nervous System
Volume13
Issue number1
DOIs
StatePublished - Mar 15 1997

Fingerprint

Meningomyelocele
Fetus
Neural Tube Defects
Amniotic Fluid
Blood Vessels
Neural Tube
Fetal Development
Spinal Cord
Cell Death
Electrons
Inflammation
Light
daminozide

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

Cite this

McLone, David G. ; Dias, Mark ; Goossens, William ; Knepper, Paul A. / Pathological changes in exposed neural tissue of fetal delayed splotch (Spd) mice. In: Child's Nervous System. 1997 ; Vol. 13, No. 1. pp. 1-7.
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Pathological changes in exposed neural tissue of fetal delayed splotch (Spd) mice. / McLone, David G.; Dias, Mark; Goossens, William; Knepper, Paul A.

In: Child's Nervous System, Vol. 13, No. 1, 15.03.1997, p. 1-7.

Research output: Contribution to journalArticle

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