Pathophysiological basis of drug-induced dyskinesias in Parkinson's disease

Milind Deogaonkar, Thyagarajan Subramanian

Research output: Contribution to journalReview article

18 Scopus citations

Abstract

Drug-induced dyskinesias (DID) represent a troublesome, dose-limiting, and common complication of long-term pharmacotherapy in Parkinson's disease (PD) patients. The pathophysiological basis and clinical nature of DID is of major interest for clinicians and neuroscientists. In this review article, we evaluate the theories of pathophysiology and molecular basis of DID, validity of various animal models used in DID related research, and electrophysiological characteristics of various basal ganglia nuclei during DID. We also discuss the relevance of various treatment strategies to the pathophysiological mechanisms.

Original languageEnglish (US)
Pages (from-to)156-168
Number of pages13
JournalBrain Research Reviews
Volume50
Issue number1
DOIs
StatePublished - Dec 1 2005

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Clinical Neurology

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