Pathophysiology and disease progression of atrial fibrillation: Importance of achieving and maintaining sinus rhythm

Marc Cohen, Gerald Naccarelli

Research output: Contribution to journalReview articlepeer-review

24 Scopus citations

Abstract

Role of Rhythm Control in Atrial Fibrillation. Atrial fibrillation (AF) is a progressive disease in which arrhythmia-induced remodeling facilitates evolution from paroxysmal AF to persistent and permanent AF. Changes in electrical, structural, and contractile properties of cardiac tissue that are thought to underlie AF maintenance and progression are reviewed. Also examined is the negative impact of AF on clinical outcomes, as well as the potential benefits of restoration and maintenance of sinus rhythm. Because of the limited efficacy and adverse effects of current antiarrhythmics, new antiarrhythmic drugs need to be developed that provide safer and more effective rhythm control in AF.

Original languageEnglish (US)
Pages (from-to)885-890
Number of pages6
JournalJournal of cardiovascular electrophysiology
Volume19
Issue number8
DOIs
StatePublished - Aug 1 2008

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Fingerprint Dive into the research topics of 'Pathophysiology and disease progression of atrial fibrillation: Importance of achieving and maintaining sinus rhythm'. Together they form a unique fingerprint.

Cite this