Pathophysiology of avian intestinal ion transport

Research output: Contribution to journalReview article

Abstract

The gut has great importance for the commercial success of poultry production. Numerous ion transporters, exchangers, and channels are present on both the apical and the basolateral membrane of intestinal epithelial cells, and their differential expression along the crypt-villus axis within the various intestinal segments ensures efficient intestinal absorption and effective barrier function. Recent studies have shown that intensive production systems, microbial exposure, and nutritional management significantly affect intestinal physiology and intestinal ion transport. Dysregulation of normal intestinal ion transport is manifested as diarrhoea, malabsorption, and intestinal inflammation resulting into poor production efficiency. This review discusses the basic mechanisms involved in avian intestinal ion transport and the impact of development during growth, nutritional and environmental alterations, and intestinal microbial infections on it. The effect of intestinal microbial infections on avian intestinal ion transport depends on factors such as host immunity, pathogen virulence, and the mucosal organisation of the particular intestinal segment.

Original languageEnglish (US)
Pages (from-to)347-360
Number of pages14
JournalWorld's Poultry Science Journal
Volume74
Issue number2
DOIs
StatePublished - Feb 28 2018

Fingerprint

ion transport
pathophysiology
malabsorption
intestinal absorption
poultry production
villi
infection
transporters
diarrhea
production technology
epithelial cells
virulence
physiology
digestive system
immunity
inflammation
ions
pathogens

All Science Journal Classification (ASJC) codes

  • Animal Science and Zoology

Cite this

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title = "Pathophysiology of avian intestinal ion transport",
abstract = "The gut has great importance for the commercial success of poultry production. Numerous ion transporters, exchangers, and channels are present on both the apical and the basolateral membrane of intestinal epithelial cells, and their differential expression along the crypt-villus axis within the various intestinal segments ensures efficient intestinal absorption and effective barrier function. Recent studies have shown that intensive production systems, microbial exposure, and nutritional management significantly affect intestinal physiology and intestinal ion transport. Dysregulation of normal intestinal ion transport is manifested as diarrhoea, malabsorption, and intestinal inflammation resulting into poor production efficiency. This review discusses the basic mechanisms involved in avian intestinal ion transport and the impact of development during growth, nutritional and environmental alterations, and intestinal microbial infections on it. The effect of intestinal microbial infections on avian intestinal ion transport depends on factors such as host immunity, pathogen virulence, and the mucosal organisation of the particular intestinal segment.",
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Pathophysiology of avian intestinal ion transport. / Nighot, Meghali; Nighot, Prashant.

In: World's Poultry Science Journal, Vol. 74, No. 2, 28.02.2018, p. 347-360.

Research output: Contribution to journalReview article

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