TY - JOUR
T1 - Pathophysiology of restless legs syndrome
T2 - Evidence for iron involvement
AU - Connor, James R.
N1 - Funding Information:
Some of the research performed and presented in this article was supported by a Program project grant from the National Institutes of Health (1 P01 AG021190) awarded to the group from Pennsylvania State University and Johns Hopkins University studying pathophysiology of RLS. I also express my gratitude to the Restless Leg Syndrome Foundation for access to the RLS Brain Donation Center and to Juan Troncoso, MD, for access to control tissue from the Johns Hopkins Brain Bank. Control tissue was also provided by the Harvard Brain Bank.
PY - 2008/3
Y1 - 2008/3
N2 - Neuroimaging, analysis of cerebrospinal fluid, and studies on postmortem tissue are generating data that support the concept that iron availability to the brain is a contributory process to, if not a cause of, restless legs syndrome. These data are reviewed and related to the dopaminergic system because of the use of dopamine agents in treating restless legs syndrome.
AB - Neuroimaging, analysis of cerebrospinal fluid, and studies on postmortem tissue are generating data that support the concept that iron availability to the brain is a contributory process to, if not a cause of, restless legs syndrome. These data are reviewed and related to the dopaminergic system because of the use of dopamine agents in treating restless legs syndrome.
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U2 - 10.1007/s11910-008-0026-x
DO - 10.1007/s11910-008-0026-x
M3 - Review article
C2 - 18460286
AN - SCOPUS:41549095416
VL - 8
SP - 162
EP - 166
JO - Current Neurology and Neuroscience Reports
JF - Current Neurology and Neuroscience Reports
SN - 1528-4042
IS - 2
ER -