Patterning surface-bound microtubules through reversible DNA hybridization

Gayatri Muthukrishnan, Caitlin A. Roberts, Yi Chun Chen, Jeffrey D. Zahn, William O. Hancock

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Biomolecular motors have great potential as transporters and actuators in microscale devices. Existing efforts toward harnessing kinesin motors have involved microtubule movements over immobilized motors. The reverse geometry has distinct advantages, but progress has been hindered by the difficulty of immobilizing patterned and aligned microtubules on surfaces. Here we show that microtubules can be reversibly patterned with microscale resolution through DNA hybridization, and that these DNA-functionalized microtubules support the movement of kinesin-coated beads.

Original languageEnglish (US)
Pages (from-to)2127-2132
Number of pages6
JournalNano letters
Volume4
Issue number11
DOIs
StatePublished - Nov 1 2004

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering

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