Patterns of care and predictors of adjuvant radiation therapy in phyllodes tumor of the breast

Oluwadamilola T. Oladeru, David D. Yang, Sung J. Ma, Joseph A. Miccio, Peter F. Orio, Laura E. Warren

Research output: Contribution to journalArticlepeer-review

Abstract

Patterns of care, utilization, and predictors of adjuvant radiation therapy (RT) for phyllodes tumors of the breast were retrospectively analyzed using the National Cancer Database. We identified 3080 patients; 53.4% received lumpectomy and 35.9% mastectomy. 25.9% of patients had lymph node sampling or dissection. 23.2% received adjuvant RT, which doubled in utilization over a decade. Predictors of RT were younger age, fewer comorbidities, less favorable pathologic features, and treatment at academic centers. There was no association between RT and overall survival (AHR 1.21, 95% CI 0.97-1.53, P =.097). Despite national guidelines recommending against nodal sampling or RT, it remains prevalent. Further research on indications for adjuvant radiation for phyllodes is needed.

Original languageEnglish (US)
Pages (from-to)1352-1357
Number of pages6
JournalBreast Journal
Volume26
Issue number7
DOIs
StatePublished - Jul 1 2020

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Surgery
  • Oncology

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