Patterns of non-traumatic myelopathies in Yaoundé (Cameroon): A hospital based study

Alain Zingraff Lekoubou Looti, André Pascal Kengne, Vincent De Paul Djientcheu, Callixte T. Kuate, Alfred K. Njamnshi

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background: The relative frequency of compressive and non-compressive myelopathies and their aetiologies have not been evaluated extensively in most sub-Saharan African countries. The case of Cameroon is studied. Methods: Admission registers and case records of patients in the neurology and neurosurgery departments of the study hospital were reviewed from January 1999 to December 2006. Results: 224 (9.7% of all admissions) cases were nontraumatic paraplegia/paraparesis or tetraplegia/ tetraparesis and 147 were due to myelopathies, representing 6.3% of all cases admitted during the study period and 65.6% of cases of paraplegia or tetraplegia; 88% were compressive myelopathies. Aetiologies were dominated by primary and secondary spinal tumours (mainly prostate carcinoma, lymphoma and liver carcinoma) that each accounted for 24.5% of cases. Other causes included spinal tuberculosis (12.9%), tropical spastic paraparesis (five positive for human T cell lymphotrophic virus (HTLV)-I and one for HTLV-II) (4.8%), spinal degenerative disease (4.1%), acute transverse myelitis (4.1%), HIV myelopathy (1.4%), vitamin B12 deficiency myelopathy and multiple sclerosis (0.7%). No aetiology was found in 21.1% of participants. Conclusions: Myelopathies in our setting are dominated by spinal compressions. Metastasis is a leading cause of spinal cord compression with liver carcinoma being more frequent than reported elsewhere. Infections nevertheless remain a major cause of spinal cord disease and both cancers and infections constitute public health targets for reducing the incidence of myelopathies.

Original languageEnglish (US)
Pages (from-to)768-770
Number of pages3
JournalJournal of Neurology, Neurosurgery and Psychiatry
Volume81
Issue number7
DOIs
StatePublished - Jul 1 2010

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Cameroon
Spinal Cord Diseases
Spinal Cord Compression
Quadriplegia
Paraplegia
Carcinoma
Transverse Myelitis
Spinal Diseases
Tropical Spastic Paraparesis
Spinal Tuberculosis
Viruses
Paraparesis
T-Lymphocytes
Vitamin B 12 Deficiency
Liver
Hospital Departments
Neurosurgery
Neurology
Infection
Multiple Sclerosis

All Science Journal Classification (ASJC) codes

  • Surgery
  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

Looti, Alain Zingraff Lekoubou ; Kengne, André Pascal ; Djientcheu, Vincent De Paul ; Kuate, Callixte T. ; Njamnshi, Alfred K. / Patterns of non-traumatic myelopathies in Yaoundé (Cameroon) : A hospital based study. In: Journal of Neurology, Neurosurgery and Psychiatry. 2010 ; Vol. 81, No. 7. pp. 768-770.
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title = "Patterns of non-traumatic myelopathies in Yaound{\'e} (Cameroon): A hospital based study",
abstract = "Background: The relative frequency of compressive and non-compressive myelopathies and their aetiologies have not been evaluated extensively in most sub-Saharan African countries. The case of Cameroon is studied. Methods: Admission registers and case records of patients in the neurology and neurosurgery departments of the study hospital were reviewed from January 1999 to December 2006. Results: 224 (9.7{\%} of all admissions) cases were nontraumatic paraplegia/paraparesis or tetraplegia/ tetraparesis and 147 were due to myelopathies, representing 6.3{\%} of all cases admitted during the study period and 65.6{\%} of cases of paraplegia or tetraplegia; 88{\%} were compressive myelopathies. Aetiologies were dominated by primary and secondary spinal tumours (mainly prostate carcinoma, lymphoma and liver carcinoma) that each accounted for 24.5{\%} of cases. Other causes included spinal tuberculosis (12.9{\%}), tropical spastic paraparesis (five positive for human T cell lymphotrophic virus (HTLV)-I and one for HTLV-II) (4.8{\%}), spinal degenerative disease (4.1{\%}), acute transverse myelitis (4.1{\%}), HIV myelopathy (1.4{\%}), vitamin B12 deficiency myelopathy and multiple sclerosis (0.7{\%}). No aetiology was found in 21.1{\%} of participants. Conclusions: Myelopathies in our setting are dominated by spinal compressions. Metastasis is a leading cause of spinal cord compression with liver carcinoma being more frequent than reported elsewhere. Infections nevertheless remain a major cause of spinal cord disease and both cancers and infections constitute public health targets for reducing the incidence of myelopathies.",
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Patterns of non-traumatic myelopathies in Yaoundé (Cameroon) : A hospital based study. / Looti, Alain Zingraff Lekoubou; Kengne, André Pascal; Djientcheu, Vincent De Paul; Kuate, Callixte T.; Njamnshi, Alfred K.

In: Journal of Neurology, Neurosurgery and Psychiatry, Vol. 81, No. 7, 01.07.2010, p. 768-770.

Research output: Contribution to journalArticle

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T1 - Patterns of non-traumatic myelopathies in Yaoundé (Cameroon)

T2 - A hospital based study

AU - Looti, Alain Zingraff Lekoubou

AU - Kengne, André Pascal

AU - Djientcheu, Vincent De Paul

AU - Kuate, Callixte T.

AU - Njamnshi, Alfred K.

PY - 2010/7/1

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N2 - Background: The relative frequency of compressive and non-compressive myelopathies and their aetiologies have not been evaluated extensively in most sub-Saharan African countries. The case of Cameroon is studied. Methods: Admission registers and case records of patients in the neurology and neurosurgery departments of the study hospital were reviewed from January 1999 to December 2006. Results: 224 (9.7% of all admissions) cases were nontraumatic paraplegia/paraparesis or tetraplegia/ tetraparesis and 147 were due to myelopathies, representing 6.3% of all cases admitted during the study period and 65.6% of cases of paraplegia or tetraplegia; 88% were compressive myelopathies. Aetiologies were dominated by primary and secondary spinal tumours (mainly prostate carcinoma, lymphoma and liver carcinoma) that each accounted for 24.5% of cases. Other causes included spinal tuberculosis (12.9%), tropical spastic paraparesis (five positive for human T cell lymphotrophic virus (HTLV)-I and one for HTLV-II) (4.8%), spinal degenerative disease (4.1%), acute transverse myelitis (4.1%), HIV myelopathy (1.4%), vitamin B12 deficiency myelopathy and multiple sclerosis (0.7%). No aetiology was found in 21.1% of participants. Conclusions: Myelopathies in our setting are dominated by spinal compressions. Metastasis is a leading cause of spinal cord compression with liver carcinoma being more frequent than reported elsewhere. Infections nevertheless remain a major cause of spinal cord disease and both cancers and infections constitute public health targets for reducing the incidence of myelopathies.

AB - Background: The relative frequency of compressive and non-compressive myelopathies and their aetiologies have not been evaluated extensively in most sub-Saharan African countries. The case of Cameroon is studied. Methods: Admission registers and case records of patients in the neurology and neurosurgery departments of the study hospital were reviewed from January 1999 to December 2006. Results: 224 (9.7% of all admissions) cases were nontraumatic paraplegia/paraparesis or tetraplegia/ tetraparesis and 147 were due to myelopathies, representing 6.3% of all cases admitted during the study period and 65.6% of cases of paraplegia or tetraplegia; 88% were compressive myelopathies. Aetiologies were dominated by primary and secondary spinal tumours (mainly prostate carcinoma, lymphoma and liver carcinoma) that each accounted for 24.5% of cases. Other causes included spinal tuberculosis (12.9%), tropical spastic paraparesis (five positive for human T cell lymphotrophic virus (HTLV)-I and one for HTLV-II) (4.8%), spinal degenerative disease (4.1%), acute transverse myelitis (4.1%), HIV myelopathy (1.4%), vitamin B12 deficiency myelopathy and multiple sclerosis (0.7%). No aetiology was found in 21.1% of participants. Conclusions: Myelopathies in our setting are dominated by spinal compressions. Metastasis is a leading cause of spinal cord compression with liver carcinoma being more frequent than reported elsewhere. Infections nevertheless remain a major cause of spinal cord disease and both cancers and infections constitute public health targets for reducing the incidence of myelopathies.

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