PCP effector proteins inturned and fuzzy play nonredundant roles in the patterning but not convergent extension of mammalian neural tube

Westley Heydeck, Aimin Liu

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

PCP effector proteins Inturned (Intu) and Fuzzy (Fuz) play important roles in mammalian neural development and ciliogenesis, but the developmental defects in Intu and Fuz mutants are not the same as those with the complete loss of cilia. Furthermore, it remains unclear whether mouse Intu and Fuz play a role in convergent extension, a process regulated by PCP signaling. In the current study, we show that the functions of both Intu and Fuz in neural tube patterning are dependent on the presence of cilia. We further show that neither gene exhibits obvious genetic interaction with the core PCP regulator Vangl2 in convergent extension or patterning of the neural tube. Finally, we show in Intu; Fuz double mutants that the lack of convergent extension and more severe patterning defects in Intu and Fuz mutants does not result from a functional redundancy between these two proteins.

Original languageEnglish (US)
Pages (from-to)1938-1948
Number of pages11
JournalDevelopmental Dynamics
Volume240
Issue number8
DOIs
StatePublished - Aug 1 2011

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Neural Tube
Cilia
Proteins
Genes

All Science Journal Classification (ASJC) codes

  • Developmental Biology

Cite this

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abstract = "PCP effector proteins Inturned (Intu) and Fuzzy (Fuz) play important roles in mammalian neural development and ciliogenesis, but the developmental defects in Intu and Fuz mutants are not the same as those with the complete loss of cilia. Furthermore, it remains unclear whether mouse Intu and Fuz play a role in convergent extension, a process regulated by PCP signaling. In the current study, we show that the functions of both Intu and Fuz in neural tube patterning are dependent on the presence of cilia. We further show that neither gene exhibits obvious genetic interaction with the core PCP regulator Vangl2 in convergent extension or patterning of the neural tube. Finally, we show in Intu; Fuz double mutants that the lack of convergent extension and more severe patterning defects in Intu and Fuz mutants does not result from a functional redundancy between these two proteins.",
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PCP effector proteins inturned and fuzzy play nonredundant roles in the patterning but not convergent extension of mammalian neural tube. / Heydeck, Westley; Liu, Aimin.

In: Developmental Dynamics, Vol. 240, No. 8, 01.08.2011, p. 1938-1948.

Research output: Contribution to journalArticle

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