Pd(II)-catalyzed cross-coupling of sp3 C-H bonds with sp 2 and sp3 boronic acids using air as the oxidant

Dong Hui Wang, Masayuki Wasa, Ramesh Giri, Jin Quan Yu

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O-Methyl hydroxamic acids, readily available from carboxylic acids, are found to be extremely reactive for β-C-H activation by Pd(OAc)2. This reactivity is exploited to develop the first example of cross-coupling sp3 C-H bonds with sp3 boronic acids. Air was shown to be a suitable stoichiometric oxidant for the catalytic oxidative coupling reaction. A biologically active natural product is readily converted to its novel analogues through this coupling reaction.

Original languageEnglish (US)
Pages (from-to)7190-7191
Number of pages2
JournalJournal of the American Chemical Society
Issue number23
StatePublished - Jun 11 2008

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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