PdII-catalyzed monoselective ortho halogenation of C-H bonds assisted by counter cations: A complementary method to directed ortho lithiation

Tian Sheng Mei, Ramesh Giri, Nathan Maugel, Jin Quan Yu

Research output: Contribution to journalArticle

277 Scopus citations

Abstract

(Chemical Equation Presented) When the counterion counts: The yield and selectivity of the title transformation of benzoic acid derivatives were improved greatly by using tetraalkyl ammonium salts as additives (see scheme; monoselectivity: 5:1-18:1). These effects are attributed to the influence of counter cations. The halogenated products are versatile intermediates for the construction of substituted aromatic compounds. DMF=N,N-dimethylformamide.

Original languageEnglish (US)
Pages (from-to)5215-5219
Number of pages5
JournalAngewandte Chemie - International Edition
Volume47
Issue number28
DOIs
StatePublished - Jun 27 2008

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)

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