Peak calf blood flow estimates are higher with Dohn than with Whitney plethysmograph

David Nathan Proctor, J. R. Halliwill, P. H. Shen, N. E. Vlahakis, M. J. Joyner, T. Eickhoff, D. Loeffler

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Estimates of calf blood flow with venous occlusion plethysmography vary widely between studies, perhaps due to the use of different plethysmographs. Consequently, we compared calf blood flow estimates at rest and during reactive hyperemia in eight healthy subjects (four men and four women) with two commonly used plethysmographs: the mercury-in-silastic (Whitney) strain gauge and the Dohn air-filled cuff. To minimize technical variability, flow estimates were compared with a Whitney gauge and a Dohn cuff on opposite calves before and after 10 mm of bilateral femoral arterial occlusion. To account for any differences between limbs, a second trial was conducted in which the plethysmographs were switched. Resting flows did not differ between the plethysmographs (P = 0.096), but a trend toward lower values with the Whitney was apparent. Peak flows averaged 37% lower with the Whitney (27.8 ± 2.8 ml·dl-1·min-1) than with the Dohn plethysmograph (44.4 ± 2.8 ml·dl-1·min-1; P < 0.05). Peak flow expressed as a multiple above baseline was also lower with the Whitney (10-fold) than with the Dohn plethysmograph (14.5-fold; P = 0.02). Across all flows at rest and during reactive hyperemia, estimates were highly correlated between the plethysmographs in all subjects (r2 = 0.96-0.99). However, the mean slope for the Whitney-Dohn relationship was only 60 ± 2%, indicating that over a wide range of flows the Whitney gauge estimate was 40% lower than that for the Dohn cuff. These results demonstrate that the same qualitative results can be obtained with either plethysmograph but that absolute flow values will generally be lower with Whitney gauges.

Original languageEnglish (US)
Pages (from-to)1418-1422
Number of pages5
JournalJournal of Applied Physiology
Volume81
Issue number3
DOIs
StatePublished - Jan 1 1996

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Hyperemia
Plethysmography
Thigh
Mercury
Healthy Volunteers
Extremities
Air
baysilon

All Science Journal Classification (ASJC) codes

  • Physiology
  • Physiology (medical)

Cite this

Proctor, D. N., Halliwill, J. R., Shen, P. H., Vlahakis, N. E., Joyner, M. J., Eickhoff, T., & Loeffler, D. (1996). Peak calf blood flow estimates are higher with Dohn than with Whitney plethysmograph. Journal of Applied Physiology, 81(3), 1418-1422. https://doi.org/10.1152/jappl.1996.81.3.1418
Proctor, David Nathan ; Halliwill, J. R. ; Shen, P. H. ; Vlahakis, N. E. ; Joyner, M. J. ; Eickhoff, T. ; Loeffler, D. / Peak calf blood flow estimates are higher with Dohn than with Whitney plethysmograph. In: Journal of Applied Physiology. 1996 ; Vol. 81, No. 3. pp. 1418-1422.
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abstract = "Estimates of calf blood flow with venous occlusion plethysmography vary widely between studies, perhaps due to the use of different plethysmographs. Consequently, we compared calf blood flow estimates at rest and during reactive hyperemia in eight healthy subjects (four men and four women) with two commonly used plethysmographs: the mercury-in-silastic (Whitney) strain gauge and the Dohn air-filled cuff. To minimize technical variability, flow estimates were compared with a Whitney gauge and a Dohn cuff on opposite calves before and after 10 mm of bilateral femoral arterial occlusion. To account for any differences between limbs, a second trial was conducted in which the plethysmographs were switched. Resting flows did not differ between the plethysmographs (P = 0.096), but a trend toward lower values with the Whitney was apparent. Peak flows averaged 37{\%} lower with the Whitney (27.8 ± 2.8 ml·dl-1·min-1) than with the Dohn plethysmograph (44.4 ± 2.8 ml·dl-1·min-1; P < 0.05). Peak flow expressed as a multiple above baseline was also lower with the Whitney (10-fold) than with the Dohn plethysmograph (14.5-fold; P = 0.02). Across all flows at rest and during reactive hyperemia, estimates were highly correlated between the plethysmographs in all subjects (r2 = 0.96-0.99). However, the mean slope for the Whitney-Dohn relationship was only 60 ± 2{\%}, indicating that over a wide range of flows the Whitney gauge estimate was 40{\%} lower than that for the Dohn cuff. These results demonstrate that the same qualitative results can be obtained with either plethysmograph but that absolute flow values will generally be lower with Whitney gauges.",
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Proctor, DN, Halliwill, JR, Shen, PH, Vlahakis, NE, Joyner, MJ, Eickhoff, T & Loeffler, D 1996, 'Peak calf blood flow estimates are higher with Dohn than with Whitney plethysmograph', Journal of Applied Physiology, vol. 81, no. 3, pp. 1418-1422. https://doi.org/10.1152/jappl.1996.81.3.1418

Peak calf blood flow estimates are higher with Dohn than with Whitney plethysmograph. / Proctor, David Nathan; Halliwill, J. R.; Shen, P. H.; Vlahakis, N. E.; Joyner, M. J.; Eickhoff, T.; Loeffler, D.

In: Journal of Applied Physiology, Vol. 81, No. 3, 01.01.1996, p. 1418-1422.

Research output: Contribution to journalArticle

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T1 - Peak calf blood flow estimates are higher with Dohn than with Whitney plethysmograph

AU - Proctor, David Nathan

AU - Halliwill, J. R.

AU - Shen, P. H.

AU - Vlahakis, N. E.

AU - Joyner, M. J.

AU - Eickhoff, T.

AU - Loeffler, D.

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N2 - Estimates of calf blood flow with venous occlusion plethysmography vary widely between studies, perhaps due to the use of different plethysmographs. Consequently, we compared calf blood flow estimates at rest and during reactive hyperemia in eight healthy subjects (four men and four women) with two commonly used plethysmographs: the mercury-in-silastic (Whitney) strain gauge and the Dohn air-filled cuff. To minimize technical variability, flow estimates were compared with a Whitney gauge and a Dohn cuff on opposite calves before and after 10 mm of bilateral femoral arterial occlusion. To account for any differences between limbs, a second trial was conducted in which the plethysmographs were switched. Resting flows did not differ between the plethysmographs (P = 0.096), but a trend toward lower values with the Whitney was apparent. Peak flows averaged 37% lower with the Whitney (27.8 ± 2.8 ml·dl-1·min-1) than with the Dohn plethysmograph (44.4 ± 2.8 ml·dl-1·min-1; P < 0.05). Peak flow expressed as a multiple above baseline was also lower with the Whitney (10-fold) than with the Dohn plethysmograph (14.5-fold; P = 0.02). Across all flows at rest and during reactive hyperemia, estimates were highly correlated between the plethysmographs in all subjects (r2 = 0.96-0.99). However, the mean slope for the Whitney-Dohn relationship was only 60 ± 2%, indicating that over a wide range of flows the Whitney gauge estimate was 40% lower than that for the Dohn cuff. These results demonstrate that the same qualitative results can be obtained with either plethysmograph but that absolute flow values will generally be lower with Whitney gauges.

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