PEDF: A multifaceted neurotrophic factor

Joyce Tombran-Tink, Colin J. Barnstable

Research output: Contribution to journalArticlepeer-review

311 Scopus citations


Pigment epithelium-derived factor (PEDF) is a potent and broadly acting neurotrophic factor that protects neurons in many regions of the central nervous system against insults such as glutamate excitotoxicity and oxidative damage. Since the crystal structure of PEDF was solved, its biological actions have begun to be mapped to specific structural domains. Here we discuss the structure and function of PEDF and the biochemical pathways it activates, and suggest ways in which this molecule might become a valuable therapeutic agent.

Original languageEnglish (US)
Pages (from-to)628-636
Number of pages9
JournalNature Reviews Neuroscience
Issue number8
StatePublished - Aug 2003

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)


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