Pediatric cancers in the new millennium: Dramatic progress, new challenges

Lisa McGregor, Monika L. Metzger, Robert Sanders, Victor M. Santana

Research output: Contribution to journalReview article

42 Citations (Scopus)

Abstract

Over the past 50 years, great strides have been made in diagnosis, treatment, and survival of childhood cancer. In the 1960s the probability of survival for a child with cancer was less than 25%, whereas today it may exceed 80%. This dramatic change has occurred through significant and steady progress in our understanding of tumor biology, creation of specialized multidisciplinary care teams, incremental improvements in therapy, establishment of specialized centers with research infrastructure to conduct pivotal clinical studies, and the evolution of a cooperative group mechanism for clinical research. Most children with cancer in the United States, Europe, and Japan receive appropriate diagnosis and treatment, although access is limited in developing countries. The price of success, however, is the growing population of survivors who require medical and psychosocial follow-up and treatment for the late effects of therapy. Here we review the progress made in pediatric oncology over the past 3 decades and consider the new challenges that face us today.

Original languageEnglish (US)
Pages (from-to)809-820
Number of pages12
JournalOncology
Volume21
Issue number7
StatePublished - Jun 1 2007

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Pediatrics
Neoplasms
Therapeutics
Survival
Research
Developing Countries
Survivors
Japan
Population

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

McGregor, L., Metzger, M. L., Sanders, R., & Santana, V. M. (2007). Pediatric cancers in the new millennium: Dramatic progress, new challenges. Oncology, 21(7), 809-820.
McGregor, Lisa ; Metzger, Monika L. ; Sanders, Robert ; Santana, Victor M. / Pediatric cancers in the new millennium : Dramatic progress, new challenges. In: Oncology. 2007 ; Vol. 21, No. 7. pp. 809-820.
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McGregor, L, Metzger, ML, Sanders, R & Santana, VM 2007, 'Pediatric cancers in the new millennium: Dramatic progress, new challenges', Oncology, vol. 21, no. 7, pp. 809-820.

Pediatric cancers in the new millennium : Dramatic progress, new challenges. / McGregor, Lisa; Metzger, Monika L.; Sanders, Robert; Santana, Victor M.

In: Oncology, Vol. 21, No. 7, 01.06.2007, p. 809-820.

Research output: Contribution to journalReview article

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McGregor L, Metzger ML, Sanders R, Santana VM. Pediatric cancers in the new millennium: Dramatic progress, new challenges. Oncology. 2007 Jun 1;21(7):809-820.