Penicillamine-induced pseudoxanthoma elasticum-like skin changes requiring rhytidectomy

G. H. Narron, N. Zec, Rogerio Neves, E. K. Manders, F. M. Sexton

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

A 42-year-old woman with pronounced skin laxity of her neck underwent a rhytidectomy and was found to have pseudoxanthoma elasticum-like changes of her skin. Her medical history was significant for Wilson's disease, requiring that she take penicillamine for 26 years. In patients on long-term penicillamine therapy, 20% to 33% will develop a dermatopathy. The drug has been used to alter scar formation in various surgical conditions. Penicillamine is known to alter cross-linking of elastin and collagen fibers. A review of the literature reveals other penicillamine-related dermatopathies that may present to the surgeon.

Original languageEnglish (US)
Pages (from-to)367-370
Number of pages4
JournalAnnals of plastic surgery
Volume29
Issue number4
DOIs
StatePublished - Jan 1 1992

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Pseudoxanthoma Elasticum
Rhytidoplasty
Penicillamine
Skin
Hepatolenticular Degeneration
Elastin
Cicatrix
Neck
Collagen
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Surgery

Cite this

Narron, G. H. ; Zec, N. ; Neves, Rogerio ; Manders, E. K. ; Sexton, F. M. / Penicillamine-induced pseudoxanthoma elasticum-like skin changes requiring rhytidectomy. In: Annals of plastic surgery. 1992 ; Vol. 29, No. 4. pp. 367-370.
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Penicillamine-induced pseudoxanthoma elasticum-like skin changes requiring rhytidectomy. / Narron, G. H.; Zec, N.; Neves, Rogerio; Manders, E. K.; Sexton, F. M.

In: Annals of plastic surgery, Vol. 29, No. 4, 01.01.1992, p. 367-370.

Research output: Contribution to journalArticle

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